Department of Veterinary Medicine, Federal University of Lavras (UFLA), Minas Gerais 37200-000, Brazil.
Department of Animal Sciences, Federal University of Lavras (UFLA), Minas Gerais 37200-000, Brazil.
Nutrients. 2018 Jan 10;10(1):65. doi: 10.3390/nu10010065.
This study evaluated the effect of the consumption of different levels and sources of lipids on metabolic parameters of Wistar rats. Animals were fed with high-fat diet (HFD) containing 20% of lard for 12 weeks to cause metabolic obesity. Subsequently, the animals were divided into six groups and were fed diets with lipid concentrations of 5% or 20% of lard (LD), soybean oil (SO) or fish oil (FO), for 4 weeks. Data were submitted to analysis of variance (two-way) followed by Tukey post hoc test ( < 0.05). The groups that consumed FO showed less weight gain and lower serum levels of triacylglycerol (TAG), total cholesterol and fractions, aspartate aminotransferase (AST) activity, atherogenic index, less amount of fat in the carcass, decreased Lee index and lower total leukocyte counting ( < 0.05). These same parameters were higher in LD treatment ( < 0.05). In the concentration of 20%, carcass fat content, blood glucose levels, as well as alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) decreased in FO groups ( < 0.05). The SO group had intermediate results regarding the other two treatments (FO and LD). We concluded that fish oil intake was able to modulate positively the metabolic changes resulting from HFD.
本研究评估了不同水平和来源的脂质摄入对 Wistar 大鼠代谢参数的影响。动物喂食高脂肪饮食（HFD），其中含有 20%的猪油，以 12 周的时间来引发代谢肥胖。随后，将动物分为六组，并喂食含有 5%或 20%猪油（LD）、大豆油（SO）或鱼油（FO）的饮食 4 周。数据采用双因素方差分析（two-way），然后进行 Tukey 事后检验（<0.05）。摄入 FO 的组体重增加较少，血清三酰甘油（TAG）、总胆固醇和各组分、天冬氨酸氨基转移酶（AST）活性、动脉粥样硬化指数、胴体脂肪含量、Lee 指数和总白细胞计数较低（<0.05）。LD 处理组的这些参数更高（<0.05）。在 20%的浓度下，FO 组的体脂含量、血糖水平以及丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）降低（<0.05）。SO 组在另外两种处理（FO 和 LD）方面的结果处于中间水平。我们得出结论，摄入鱼油能够积极调节 HFD 引起的代谢变化。
