O'Brien T F, Steindler D A, Cooper N G
Brain Res. 1987 Apr;429(2):309-17. doi: 10.1016/0165-3806(87)90112-x.
During early postnatal development in reeler mutant mice, lectin binding delineates prospective abnormal barrels as they will appear in the adult mutant somatosensory cortex. Glial fibers also may be more condensed within fascicles in developing reeler barrels. These fibers also appear to be misaligned, coursing predominantly in the tangential plane within the abnormal reeler barrel sides as opposed to having a radial orientation as seen in normal mouse barrels. The thalamic barreloid complex, however, reveals a disposition of glycoconjugates that is completely normal in reeler. Thus, there are anomalies in glia and associated glycoconjugates during mainly cortical development in the reeler mutant mouse that might be related to the primary action of the abnormal gene.
在reeler突变小鼠出生后的早期发育阶段，凝集素结合勾勒出了未来会出现在成年突变体躯体感觉皮层中的异常桶状结构。在发育中的reeler桶状结构内，神经胶质纤维在束内可能也更为密集。这些纤维似乎排列紊乱，主要在异常的reeler桶状结构侧面的切线平面内走行，而不像正常小鼠桶状结构那样呈放射状排列。然而，丘脑桶状复合体显示，reeler小鼠中糖缀合物的分布完全正常。因此，在reeler突变小鼠主要的皮层发育过程中，神经胶质细胞和相关糖缀合物存在异常，这可能与异常基因的主要作用有关。
