Cooper N G, Steindler D A
Brain Res. 1986 Aug 20;380(2):341-8. doi: 10.1016/0006-8993(86)90232-5.
The relative dispositions of cells in immature and mature mouse barrel field cortices that bind antibody to glial fibrillary acidic protein (GFAP) were examined and photographed under the light microscope. Light micrographs demonstrate that radially oriented glial cells are present in the barrel field of postnatal day 6 cortices and that they are located predominantly within the presumptive barrel sides and/or septae, thus sharply delineating individual barrels from each other. The relative dispositions of radial glial fibers observed at this time implicate glia in development of topographic order during early postnatal development of the somatosensory cortex. In contrast, no such delineation could be detected in the cortices of more mature mice, because GFAP-positive astrocytes are present throughout the barrel field and are not confined to barrel sides. This ephemeral nature of the GFAP-delineated barrel field is of interest with respect to the recently reported ephemeral lectin-delineated barrel field.
在光学显微镜下检查并拍摄了未成熟和成熟小鼠桶状皮质中与胶质纤维酸性蛋白（GFAP）抗体结合的细胞的相对分布情况。光学显微镜照片显示，在出生后第6天的皮质桶状区存在呈放射状排列的胶质细胞，且它们主要位于假定的桶壁和/或隔膜内，从而将各个桶彼此清晰地分隔开。此时观察到的放射状胶质纤维的相对分布表明，胶质细胞在体感皮层出生后早期发育过程中的地形顺序形成中发挥作用。相比之下，在更成熟小鼠的皮质中未检测到这种分隔，因为GFAP阳性星形胶质细胞遍布整个桶状区，并不局限于桶壁。GFAP描绘的桶状区的这种短暂性质，与最近报道的短暂的凝集素描绘的桶状区有关，值得关注。
