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Identification and characterisation of SARS-CoV-2 and Human alphaherpesvirus 1 from a productive coinfection in a fatal COVID-19 case.从一例致死性 COVID-19 病例中的有效合并感染中鉴定和特征分析 SARS-CoV-2 和人单纯疱疹病毒 1。
Mem Inst Oswaldo Cruz. 2022 Jan 10;116:e210176. doi: 10.1590/0074-02760210176. eCollection 2022.
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Validation of a novel molecular assay to the diagnostic of COVID-19 based on real time PCR with high resolution melting.一种新型分子检测方法的验证，该方法基于实时 PCR 和高分辨率熔解曲线分析，用于 COVID-19 的诊断。
PLoS One. 2021 Nov 22;16(11):e0260087. doi: 10.1371/journal.pone.0260087. eCollection 2021.
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Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases.NMDA 受体的分子模拟可能与严重 COVID-19 病例中的神经精神症状有关。
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Presence and clinical impact of human herpesvirus-6 infection in patients with moderate to critical coronavirus disease-19.人疱疹病毒 6 感染在中至危重症 2019 冠状病毒病患者中的存在及临床影响。
J Med Virol. 2022 Mar;94(3):1212-1216. doi: 10.1002/jmv.27392. Epub 2021 Oct 19.
5
Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study.新型冠状病毒肺炎患者的单纯疱疹病毒再激活：一项前瞻性观察研究。
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A Rare Case of Human Herpesvirus 6 Meningitis in an Immunocompetent Asian Male Presented With a Severe Intractable Headache.一名免疫功能正常的亚洲男性患人疱疹病毒6型脑膜炎的罕见病例，表现为严重的顽固性头痛。
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Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation.“长新冠”患病率及其与爱泼斯坦-巴尔病毒再激活关系的调查
Pathogens. 2021 Jun 17;10(6):763. doi: 10.3390/pathogens10060763.

疱疹病毒与重症新型冠状病毒病患者的神经表现。

Herpesvirus and neurological manifestations in patients with severe coronavirus disease.

机构信息

Laboratory of Molecular Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.

Laboratory of Technological Development in Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.

出版信息

Virol J. 2022 Jun 8;19(1):101. doi: 10.1186/s12985-022-01828-9.

DOI:10.1186/s12985-022-01828-9
PMID:35676707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9174631/
Abstract

BACKGROUND

Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.

METHODS

We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.

RESULTS

Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).

CONCLUSIONS

The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.

摘要

背景

冠状病毒病（COVID-19）的某些临床表现与人类疱疹病毒（HHV）感染有关。在这项研究中，我们估计了 COVID-19 患者中疱疹病毒的流行情况，并确定了合并感染是否与较差的结局和神经症状有关。

方法

我们分析了 53 名确诊 COVID-19 患者的样本。使用定量聚合酶链反应（qPCR）方法评估样本中是否存在α疱疹病毒、β疱疹病毒和γ疱疹病毒，并定量检测病毒载量。

结果

在患者中，79.2%的患者至少检测到一种类型的疱疹病毒。HHV-6（47.2%）、巨细胞病毒（43.3%）和 HHV-7（39.6%）的检出率最高。高载量严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的患者更有可能检测到单纯疱疹病毒 1（p=0.037）。在 SARS-CoV-2 和 HHVs 合并感染的患者中，26.4%出现与中枢神经系统相关的神经症状和疱疹表现。在神经变化和 HHV-6 检测之间观察到统计学显著关联（p=0.034）。

结论

研究结果表明 COVID-19 患者中疱疹病毒的流行率很高。此外，尽管 SARS-CoV-2 和 HHV 合并感染与较差的结局无关，但研究结果表明神经症状与 HHV-6 检测之间存在关联。