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本文引用的文献

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Sex differences in the immune response to acute COVID-19 respiratory tract infection.急性 COVID-19 呼吸道感染的免疫反应中的性别差异。
Biol Sex Differ. 2021 Dec 20;12(1):66. doi: 10.1186/s13293-021-00410-2.
2
Sex Differences in COVID-19 Hospitalization and Mortality.性别差异与 COVID-19 住院和死亡率。
J Womens Health (Larchmt). 2021 May;30(5):646-653. doi: 10.1089/jwh.2020.8948. Epub 2021 Apr 7.
3
Sex Differences on Clinical Characteristics, Severity, and Mortality in Adult Patients With COVID-19: A Multicentre Retrospective Study.2019年冠状病毒病成年患者临床特征、严重程度及死亡率的性别差异:一项多中心回顾性研究
Front Med (Lausanne). 2021 Feb 12;8:607059. doi: 10.3389/fmed.2021.607059. eCollection 2021.
4
Sex differences in susceptibility, severity, and outcomes of coronavirus disease 2019: Cross-sectional analysis from a diverse US metropolitan area.性别差异在 2019 冠状病毒病的易感性、严重程度和结局中的作用:来自美国多元化大都市地区的横断面分析。
PLoS One. 2021 Jan 13;16(1):e0245556. doi: 10.1371/journal.pone.0245556. eCollection 2021.
5
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.全球 COVID-19 荟萃分析显示,男性性别是死亡和 ICU 入院的风险因素。
Nat Commun. 2020 Dec 9;11(1):6317. doi: 10.1038/s41467-020-19741-6.
6
The "sex gap" in COVID-19 trials: a scoping review.新冠病毒疾病试验中的“性别差异”:一项范围综述
EClinicalMedicine. 2020 Dec;29:100652. doi: 10.1016/j.eclinm.2020.100652. Epub 2020 Nov 30.
7
COVID-19 and Sex Differences: Mechanisms and Biomarkers.COVID-19 与性别差异:机制与生物标志物。
Mayo Clin Proc. 2020 Oct;95(10):2189-2203. doi: 10.1016/j.mayocp.2020.07.024. Epub 2020 Aug 4.
8
Sex differences in severity and mortality from COVID-19: are males more vulnerable?新冠病毒感染所致严重程度和死亡率的性别差异:男性更易感染吗?
Biol Sex Differ. 2020 Sep 18;11(1):53. doi: 10.1186/s13293-020-00330-7.
9
Racial and Gender-Based Differences in COVID-19.新冠病毒感染的种族和性别差异。
Front Public Health. 2020 Jul 28;8:418. doi: 10.3389/fpubh.2020.00418. eCollection 2020.
10
Men and COVID-19: A Biopsychosocial Approach to Understanding Sex Differences in Mortality and Recommendations for Practice and Policy Interventions.男性与 COVID-19:理解死亡率性别差异的生物心理社会方法及对实践和政策干预的建议。
Prev Chronic Dis. 2020 Jul 16;17:E63. doi: 10.5888/pcd17.200247.

将女性排除在 COVID-19 研究之外会损害妇女的健康,并减缓我们对大流行病的应对速度。

Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics.

机构信息

, Lexington, KY, USA.

出版信息

Biol Sex Differ. 2022 Jun 8;13(1):27. doi: 10.1186/s13293-022-00435-1.

DOI:10.1186/s13293-022-00435-1
PMID:35676733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9175518/
Abstract

Sex and gender inclusion are crucial in bringing COVID-19 to an end and preventing the next pandemic. Despite this, almost all research studies on COVID-19 and clinical trials of vaccines do not include data on women. How can we combat the pandemic if half of the human population is left out of COVID-19 research? The life-long consequences of this neglect could be severe for women all over the world, particularly with the emergence of new variants that could exaggerate sex differences even further. Here I review recent studies and argue that taking a gender/sex approach to the study of this pandemic would expedite its end and improve the general health of women in substantial ways.

摘要

将性别平等纳入考量对于终结新冠疫情和防止下一次大流行至关重要。然而,几乎所有关于新冠疫情的研究和疫苗临床试验都没有纳入女性的数据。如果将一半的人口排除在新冠研究之外,我们如何能够抗击疫情?这种忽视可能会给全世界的女性带来严重的后果,尤其是随着新变体的出现,可能会进一步加剧性别差异。在此,我回顾了最近的研究,并认为采取一种性别方法来研究这场大流行将加速其终结,并在很大程度上改善女性的整体健康状况。