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病例报告:一名复发缓解型多发性硬化症患者接受富马酸二甲酯治疗后出现巴洛同心性硬化样病变

Case Report: Baló's Concentric Sclerosis-Like Lesion in a Patient With Relapsing-Remitting Multiple Sclerosis Treated With Dimethyl Fumarate.

作者信息

Kania Karolina, Ambrosius Wojciech, Kozubski Wojciech, Kalinowska Alicja

机构信息

Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Front Neurol. 2022 May 23;13:891113. doi: 10.3389/fneur.2022.891113. eCollection 2022.

DOI:10.3389/fneur.2022.891113
PMID:35677328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9168072/
Abstract

Baló's concentric sclerosis (BCS) is a rare demyelinating disorder characterized by acute or subacute neurological symptoms associated with characteristic lesions of concentric onion skin appearance on MRI images and in pathology. The connection between BCS and classic MS is still a subject of debates. Our report presents a case of a patient who developed a symptomatic Baló-like lesion following several years of classical relapsing-remitting multiple sclerosis treated with dimethyl fumarate.

摘要

巴洛同心性硬化(BCS)是一种罕见的脱髓鞘疾病,其特征为急性或亚急性神经症状,与MRI图像及病理学上具有特征性的同心洋葱皮样病变相关。BCS与经典型多发性硬化症之间的联系仍是一个有争议的话题。我们的报告介绍了一例患者,该患者在接受富马酸二甲酯治疗数年的经典复发缓解型多发性硬化症后出现了有症状的巴洛样病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845a/9168072/315aa685bd40/fneur-13-891113-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845a/9168072/315aa685bd40/fneur-13-891113-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845a/9168072/315aa685bd40/fneur-13-891113-g0001.jpg

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本文引用的文献

1
Clinical and Radiologic Features, Pathology, and Treatment of Baló Concentric Sclerosis.Baló 同心圆性硬化的临床和放射学特征、病理学和治疗。
Neurology. 2021 Jul 27;97(4):e414-e422. doi: 10.1212/WNL.0000000000012230. Epub 2021 May 19.
2
Heterogeneity of Baló's concentric sclerosis: a study of eight cases with different therapeutic concepts.巴洛同心圆硬化的异质性:八种不同治疗理念病例的研究。
BMC Neurol. 2020 Nov 2;20(1):400. doi: 10.1186/s12883-020-01971-2.
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Tumefactive multiple sclerosis in association with fingolimod initiation and discontinuation.
与芬戈莫德起始和停药相关的肿胀型多发性硬化症。
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From Baló's concentric sclerosis to multiple sclerosis: a series of 6 patients.从巴洛氏同心硬化到多发性硬化症:一系列 6 例患者。
Mult Scler Relat Disord. 2020 Jul;42:102078. doi: 10.1016/j.msard.2020.102078. Epub 2020 May 4.
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A tumefactive demyelinating lesion in a person with MS after five years of fingolimod.一名多发性硬化症患者在使用芬戈莫德五年后出现肿块样脱髓鞘病变。
Mult Scler Relat Disord. 2020 May;40:101978. doi: 10.1016/j.msard.2020.101978. Epub 2020 Jan 31.
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7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions.巴洛同心性硬化与多发性硬化病变的7特斯拉磁共振成像
Ann Clin Transl Neurol. 2018 Jun 29;5(8):900-912. doi: 10.1002/acn3.572. eCollection 2018 Aug.
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Balo's concentric sclerosis: an update and comprehensive literature review.Balo 同心圆性硬化:更新及全面文献复习。
Rev Neurosci. 2018 Nov 27;29(8):873-882. doi: 10.1515/revneuro-2017-0096.
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Baló's concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures.巴洛氏同心性硬化症在免疫学上有别于多发性硬化症:近 150 次腰椎穿刺的回顾性分析结果。
J Neuroinflammation. 2018 Jan 18;15(1):22. doi: 10.1186/s12974-017-1043-y.
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Neurological safety of fingolimod: An updated review.芬戈莫德的神经安全性:最新综述。
Clin Exp Neuroimmunol. 2017 Aug;8(3):233-243. doi: 10.1111/cen3.12397. Epub 2017 Jun 18.
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Atypical inflammatory demyelinating syndromes of the CNS.中枢神经系统非典型炎症性脱髓鞘综合征。
Lancet Neurol. 2016 Aug;15(9):967-981. doi: 10.1016/S1474-4422(16)30043-6.