Ghassemi Fariba, Bazvand Fatemeh, Faghihi Houshang, Roohipourmoallai Ramak, Masoumi Maryam, Jamali Sepide, Mohebbi Masoumeh, Sabour Siamak
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
The Retina and Vitreous Surgery Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Ophthalmol. 2022 May 30;2022:6831396. doi: 10.1155/2022/6831396. eCollection 2022.
To characterize results of short-wavelength autofluorescent (SW-AF) and near-infrared confocal reflectance scanning laser ophthalmoscopy (NIR-cR SLO) imaging in cystic diabetic macular edema (DME).
Cross-sectional study. Participants: 104 eyes from 52 naïve treatment patients with DME and mild to moderate nonproliferative diabetic retinopathy (NPDR) Methods: complete ocular examination, best-corrected visual acuity (BCVA), and imaging were performed.
In NIR-cR SLO, small/medium and large-sized cysts presented with decreased and increased reflectance, respectively. In SW-AF, increased and decreased autofluorescence, corresponding to medium-/large- and small-sized cysts were noted. Mainly, the lower NIR reflectance was associated with petaloid edema pattern in SW-AF (=0.011), BCVA (logMAR) (=0.056), subretinal fluid (=0.035), and the involved layers of retina by cysts ( < 0.001) in Pearson chi-square test. Fair agreement of 0.31 ( < 0.001) between NIR-cR SLO and late FA leakage was found by the weighted kappa test. In regression analysis, NIR-cR SLO abnormality is highly correlated with outer and inner nuclear layers location of the cystic changes.
The size of cysts and involved layers affect presenting features of SW-AF and NIR reflectance.
描述短波自发荧光（SW-AF）和近红外共焦反射扫描激光眼科检查（NIR-cR SLO）成像在囊性糖尿病性黄斑水肿（DME）中的结果。
横断面研究。参与者：52例初治的DME和轻度至中度非增殖性糖尿病视网膜病变（NPDR）患者的104只眼。方法：进行全面的眼部检查、最佳矫正视力（BCVA）和成像。
在NIR-cR SLO中，中小囊肿和大囊肿分别表现为反射率降低和升高。在SW-AF中，观察到与中/大囊肿和小囊肿相对应的自发荧光增强和减弱。在Pearson卡方检验中，主要是较低的NIR反射率与SW-AF中的花瓣状水肿模式（=0.011）、BCVA（logMAR）（=0.056）、视网膜下液（=0.035）以及囊肿累及的视网膜层（<0.001）相关。通过加权kappa检验发现NIR-cR SLO与晚期荧光素血管造影渗漏之间的一致性良好，为0.31（<0.001）。在回归分析中，NIR-cR SLO异常与囊肿变化的外核层和内核层位置高度相关。
囊肿大小和累及的视网膜层影响SW-AF和NIR反射率的表现特征。
