Salmon R J, Buisson J P, Demerseman P, Einhorn J, Aussepe L, Zafrani B, Royer R
Cancer Lett. 1987 Apr;35(1):59-64. doi: 10.1016/0304-3835(87)90056-5.
7-Methoxy-2-nitro-naphtho[2,1-b]furan (R 7000) and its methylated homolog in position 1 (R 7372) are among the most mutagenic agents presently known, as shown by the results obtained both in the Ames test and in the SOS Chromotest. Their carcinogenic effects were tested in rats. We were able to confirm the carcinogenic effects of these nitro-naphthofurans, the presence of a methyl group--while increasing the mutagenic effect of R 7000 10 times--induces a significant decrease of the carcinogenic effects in R 7372. The discrepancy between the mutagenic effects in bacterial assays and the carcinogenic effects of these two 2-nitro-naphthofurans remains to be explained.
7-甲氧基-2-硝基萘并[2,1-b]呋喃（R 7000）及其1位甲基化同系物（R 7372）是目前已知的最具致突变性的物质之一，这已由艾姆斯试验和SOS色变试验所获得的结果表明。它们对大鼠进行了致癌作用测试。我们能够证实这些硝基萘并呋喃的致癌作用，甲基的存在——虽然使R 7000的致突变作用增加了10倍——却导致R 7372的致癌作用显著降低。这两种2-硝基萘并呋喃在细菌试验中的致突变作用与致癌作用之间的差异仍有待解释。
