Research Genetic Cancer Centre S.A., Industrial Area of Florina, Greece.
Research Genetic Cancer Centre International GmbH, Zug, Switzerland.
Cancer Treat Res Commun. 2022;32:100575. doi: 10.1016/j.ctarc.2022.100575. Epub 2022 May 13.
Patients with cancer require efficient treatment approaches as the mortality rate due to their disease is high. Conventional therapies, like chemotherapy and radiation, have severe side effects. Drug discovery is focusing on the development of alternative strategies that could have beneficial effects to the patients. Cellular therapies are potential therapeutics, and the generation of new products is growing fast. The concept involves the isolation of immune cells, ex vivo activation and reinfusion into the patient. The goal is to boost the immune cells to fight cancer cells. Different immune cells can be used, including dendritic cells, T cells, NK cells, macrophages and B lymphocytes. Some products have already gained FDA approval, while many more are currently in clinical trials. Research is focusing on the improvement of the function of the cells that may require genetic modification or combination with other therapies. Finally, it is crucial to develop novel technologies that could be used in monitoring of the immune profile of patients that have received a cellular therapy to assess the efficacy of the treatment.
癌症患者需要高效的治疗方法，因为他们的死亡率很高。传统疗法，如化疗和放疗，有严重的副作用。药物研发专注于开发可能对患者有有益效果的替代策略。细胞疗法是一种有潜力的治疗方法，新产品的开发速度很快。这个概念涉及免疫细胞的分离、体外激活和再输注到患者体内。其目的是增强免疫细胞来对抗癌细胞。可以使用不同的免疫细胞，包括树突状细胞、T 细胞、自然杀伤细胞、巨噬细胞和 B 淋巴细胞。一些产品已经获得了 FDA 的批准，而更多的产品目前正在临床试验中。研究的重点是改善细胞的功能，这可能需要基因修饰或与其他疗法结合。最后，开发新的技术来监测接受细胞疗法的患者的免疫谱是至关重要的，以评估治疗的效果。
