Centre of Biomedical Engineering, School of Biological Science, University of Reading, Reading, UK.
Centre for Rehabilitation Engineering and Assistive Technology, University College London, London, UK.
Spinal Cord Ser Cases. 2022 Jun 10;8(1):60. doi: 10.1038/s41394-022-00523-9.
A training intervention study using standing dynamic load-shifting Functional Electrical Stimulation (FES) in a group of individuals with complete spinal cord injury (SCI) T2 to T10.
Investigate the effect of FES-assisted dynamic load-shifting exercises on bone mineral density (BMD).
University Lab within the Biomedical Engineering METHODS: Twelve participants with ASIA A SCI were recruited for this study. Three participants completed side-to-side load-shifting FES-assisted exercises for 29 ± 5 weeks, 2× per week for 1 h, and FES knee extension exercises on alternate days 3× per week for 1 h. Volumetric Bone Mineral density (vBMD) at the distal femur and tibia were assessed using peripheral quantitative computed tomography (pQCT) before and after the intervention study.
Participants with acute and subacute SCI showed an absolute increase of f trabecular vBMD (vBMD) in the proximal (mean of 26.9%) and distal tibia (mean of 22.35%). Loss of vBMD in the distal femur was observed.
Improvements in vBMD in the distal tibia were found in acute and subacute SCI participants, and in the proximal tibia of acute participants, when subjected to anti-gravity FES-assisted load-bearing exercises for 29 ± 5 weeks. No vBMD improvement in distal femur or tibial shaft were observed in any of the participants as was expected. However, improvements of vBMD in the proximal and distal tibia were observed in two participants. This study provides evidence of an improvement of vBMD, when combining high-intensity exercises with lower intensity exercises 5× per week for 1 h.
一项针对 T2 至 T10 完全性脊髓损伤（SCI）患者的站立动态负荷转移功能性电刺激（FES）训练干预研究。
研究 FES 辅助动态负荷转移训练对骨密度（BMD）的影响。
大学实验室，生物医学工程专业。
本研究招募了 12 名 ASIA A SCI 参与者。3 名参与者完成了 29±5 周的侧-侧负荷转移 FES 辅助运动，每周 2 次，每次 1 小时，每周 3 次，每天交替进行 FES 膝关节伸展运动，每次 1 小时。在干预研究前后，使用外周定量计算机断层扫描（pQCT）评估远端股骨和胫骨的体积骨密度（vBMD）。
急性和亚急性 SCI 参与者的胫骨近端（平均增加 26.9%）和远端（平均增加 22.35%）的小梁 vBMD 出现绝对增加。在远端股骨观察到 vBMD 丢失。
在接受 29±5 周的抗重力 FES 辅助负重运动后，急性和亚急性 SCI 参与者的胫骨远端和急性参与者的胫骨近端的 vBMD 均有所改善。在任何参与者中，都没有观察到远端股骨或胫骨骨干的 vBMD 改善，这是预期的。然而，两名参与者的胫骨近端和远端的 vBMD 都有所改善。这项研究提供了证据，表明当将高强度运动与每周 5 次、每次 1 小时的低强度运动结合使用时，可以提高 vBMD。
