Liu Xuanyou, Wu Hao, Liu Zhenguo
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Cancers (Basel). 2022 May 27;14(11):2658. doi: 10.3390/cancers14112658.
Cyclin-dependent kinase 1 (CDK1) is essential for cell division by regulating the G2/M phase and mitosis. CDK1 overexpression can also promote the development and progression of a variety of cancers. However, the significance of CDK1 in the formation, progression, and prognosis of human pan-cancer remains unclear. In the present study, we used The Cancer Genome Atlas database, Clinical Proteomic Tumor Analysis Consortium, Human Protein Atlas, Genotype-Tissue Expression, and other well-established databases to comprehensively examine CDK1 genetic alterations and gene/protein expression in various cancers and their relationships with the prognosis, immune reactivities, and clinical outcomes for 33 tumor types. Gene set enrichment analysis was also conducted to examine the potential mechanisms of CDK1 in tumorigenesis. The data showed that mutation was frequently present in multiple tumors. CDK1 expression was significantly increased in various types of tumors as compared with normal tissues and was associated with poor overall and disease-free survival. In addition, CDK1 expression was significantly correlated with oncogenic genes, proteins, cellular components, myeloid-derived suppressor cell infiltration, ESTMATEScore, and signaling pathways associated with tumor development and progression and tumor microenvironments. These data indicate that CDK1 could serve as a promising biomarker for predicting tumor prognosis and a potential target for cancer treatment.
细胞周期蛋白依赖性激酶1（CDK1）通过调节G2/M期和有丝分裂对细胞分裂至关重要。CDK1的过表达也可促进多种癌症的发生和发展。然而，CDK1在人类泛癌的形成、进展和预后中的意义仍不清楚。在本研究中，我们使用癌症基因组图谱数据库、临床蛋白质组肿瘤分析联盟、人类蛋白质图谱、基因型-组织表达以及其他成熟的数据库，全面研究了CDK1在各种癌症中的基因改变和基因/蛋白质表达，及其与33种肿瘤类型的预后、免疫反应性和临床结果的关系。还进行了基因集富集分析，以研究CDK1在肿瘤发生中的潜在机制。数据显示，多种肿瘤中经常出现突变。与正常组织相比，CDK1在各种类型的肿瘤中表达显著增加，并且与总体生存率和无病生存率低相关。此外，CDK1表达与致癌基因、蛋白质、细胞成分、髓源性抑制细胞浸润、ESTMATEScore以及与肿瘤发生发展和肿瘤微环境相关的信号通路显著相关。这些数据表明，CDK1可作为预测肿瘤预后的有前景的生物标志物和癌症治疗的潜在靶点。
