Tsai I-Chen, Hsu Chih-Wei, Chang Chun-Hung, Tseng Ping-Tao, Chang Ke-Vin
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Congenital Heart Disease Study Group, Asian Society of Cardiovascular Imaging, Seoul 13572, Korea.
Pharmaceuticals (Basel). 2021 Nov 28;14(12):1235. doi: 10.3390/ph14121235.
Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects that has been shown to be effective in ameliorating cognitive decline in animal studies. However, its clinical effectiveness is inconclusive, and relevant gastrointestinal adverse events (AEs) have been reported. The aim of this meta-analysis was to summarize the existing evidence from randomized controlled trials (RCTs) of effects of curcumin on overall cognitive function, individual cognitive domains, and gastrointestinal AE. The study includes 8 RCTs and 389 participants. A random-effects model was used for the meta-analysis. Compared with the placebo group, the curcumin group was associated with an improvement in working memory (Hedges' = 0.396, 95% confidence interval (CI) = 0.078 to 0.714, = 0.015) and a borderline benefit in processing speed (Hedges' = 0.303, 95% CI = -0.013 to 0.619, = 0.06). In the domains of language, episodic memory/visual learning, verbal memory, cognitive flexibility/problem solving, and overall cognitive function, no significant difference existed for the comparison between the curcumin and placebo groups. The curcumin group had a significantly higher risk of gastrointestinal AEs than the placebo group (odds ratio = 3.019, 95% CI = 1.118 to 8.150, = 0.029). In the future, the effects of curcumin on working memory, processing speed, and gastrointestinal AE should be further investigated.
姜黄素是一种具有强大抗氧化和抗炎作用的多酚，在动物研究中已显示出对改善认知衰退有效。然而，其临床疗效尚无定论，且已报告了相关的胃肠道不良事件（AE）。本荟萃分析的目的是总结来自随机对照试验（RCT）的现有证据，以探讨姜黄素对整体认知功能、个体认知领域和胃肠道AE的影响。该研究纳入了8项RCT和389名参与者。采用随机效应模型进行荟萃分析。与安慰剂组相比，姜黄素组在工作记忆方面有所改善（Hedges' = 0.396，95%置信区间（CI） = 0.078至0.714，P = 0.015），在处理速度方面有边缘性益处（Hedges' = 0.303，95% CI = -0.013至0.619，P = 0.06）。在语言、情景记忆/视觉学习、言语记忆、认知灵活性/问题解决以及整体认知功能等领域，姜黄素组与安慰剂组相比无显著差异。姜黄素组胃肠道AE的风险显著高于安慰剂组（优势比 = 3.019，95% CI = 1.118至8.150，P = 0.029）。未来，应进一步研究姜黄素对工作记忆、处理速度和胃肠道AE的影响。
