Implantation and Pregnancy Research Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology, Bundoora, VIC 3083, Australia.
Int J Mol Sci. 2022 Jun 1;23(11):6210. doi: 10.3390/ijms23116210.
Development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Understanding the molecular regulation underpinning endometrial transformation to a receptive state is key to improving implantation rates in fertility treatments such as IVF. With microRNAs (miRNAs) increasingly recognized as important gene regulators, recent studies have investigated the role of miRNAs in the endometrium. Studies on miRNAs in endometrial disorders such as endometriosis and endometrial cancer have been reviewed previously. In this minireview, we aim to provide an up-to-date knowledge of miRNAs in the regulation of endometrial receptivity. Since endometrial remodelling differs considerably between species, we firstly summarised the key events of the endometrial cycle in humans and mice and then reviewed the miRNAs identified so far in these two species with likely functional significance in receptivity establishment. To date, 29 miRNAs have been reported in humans and 15 miRNAs in mice within various compartments of the endometrium that may potentially modulate receptivity; miRNAs regulating the Wnt signalling and those from the let-7, miR-23, miR-30, miR-200 and miR-183 families are found in both species. Future studies are warranted to investigate miRNAs as biomarkers and/or therapeutic targets to detect/improve endometrial receptivity in human fertility treatment.
子宫内膜容受性的发展对于胚胎着床和妊娠的成功至关重要。了解支持子宫内膜向接受状态转化的分子调控机制是提高体外受精等生育治疗中着床率的关键。随着 microRNAs（miRNAs）越来越被认为是重要的基因调控因子，最近的研究已经调查了 miRNAs 在子宫内膜中的作用。以前已经对 miRNA 在子宫内膜疾病（如子宫内膜异位症和子宫内膜癌）中的作用进行了综述。在这篇小型综述中，我们旨在提供 miRNA 在调节子宫内膜容受性方面的最新知识。由于物种间的子宫内膜重塑有很大的不同，我们首先总结了人类和小鼠子宫内膜周期的关键事件，然后综述了迄今为止在这两个物种中发现的可能在接受性建立中具有功能意义的 miRNAs。迄今为止，在人类的不同子宫内膜区域已报道了 29 个 miRNAs，在小鼠中已报道了 15 个 miRNAs，这些 miRNAs 可能潜在地调节接受性；在这两个物种中都发现了调节 Wnt 信号通路的 miRNAs，以及来自 let-7、miR-23、miR-30、miR-200 和 miR-183 家族的 miRNAs。有必要进行未来的研究，以调查 miRNAs 作为生物标志物和/或治疗靶点，以检测/改善人类生育治疗中的子宫内膜容受性。
