College of Animal Sciences, Zhejiang University, Hangzhou, China.
Front Endocrinol (Lausanne). 2022 Jan 28;13:809596. doi: 10.3389/fendo.2022.809596. eCollection 2022.
Extracellular vesicles (EVs) are membrane-coating nanoparticles derived from cells. The effect of cell-to-cell communication mediated by EVs has been investigated in different fields of physio-logical as well as pathological process in recent years. Reproduction, regarded as a definitive characteristic of organisms, has been a focus in both animal and medical sciences. It is well agreed that implantation is a critical event during early pregnancy in viviparous animals, and a proper implantation is essential for the establishment and maintenance of normal pregnancy. However, successful implantation requires the synchronized development of both the uterus and the embryo, therefore, in which well communication and opportune regulation are necessary. This review focuses on the progression of studies that reveal the role of EVs in early pregnancy, especially during implantation. Based on current evidence, EVs are produced and exist in the environment for implantation. It has been proved that EVs of different origins such as endometrium and embryo, have positive influences on embryo implantation. With their cargos of proteins and nucleic acids (especially microRNAs), EVs exert their effects including information transportation, immune stimulation and regulation of gene expression.
细胞外囊泡 (EVs) 是源自细胞的膜包裹纳米颗粒。近年来，EVs 介导的细胞间通讯的影响在生理和病理过程的不同领域得到了研究。生殖被认为是生物体的一个决定性特征，一直是动物学和医学科学的焦点。人们普遍认为，在胎生动物的早期妊娠中，着床是一个关键事件，适当的着床对于建立和维持正常妊娠是至关重要的。然而，成功的着床需要子宫和胚胎的同步发育，因此，良好的通讯和适时的调节是必要的。本综述重点介绍了揭示 EVs 在早期妊娠，特别是着床过程中作用的研究进展。基于目前的证据，EVs 是在着床环境中产生和存在的。已经证明，来自子宫内膜和胚胎等不同来源的 EVs 对胚胎着床有积极的影响。EVs 通过其携带的蛋白质和核酸（特别是 microRNAs）发挥作用，包括信息传递、免疫刺激和基因表达的调节。
