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三尖瓣闭锁或单心室患者接受Fontan手术后主肺动脉内的血流动力学

Flow dynamics in the main pulmonary artery after the Fontan procedure in patients with tricuspid atresia or single ventricle.

作者信息

Nakazawa M, Nojima K, Okuda H, Imai Y, Nakanishi T, Kurosawa H, Takao A

出版信息

Circulation. 1987 Jun;75(6):1117-23. doi: 10.1161/01.cir.75.6.1117.

Abstract

We analyzed the flow velocity pattern in the main pulmonary artery after Fontan operation in patients with tricuspid atresia (n = 10) or with single ventricle (n = 10) by means of a catheter-mounted velocity probe. The area underneath the velocity signal of the forward flow was integrated, and ratios of the portions during atrial systole and during the diastolic phase to the total area (Fa and Fd) were calculated. The Fa was 0.54 +/- 0.09 in patients with tricuspid atresia and 0.45 +/- 0.05 in those with single ventricle (p less than .01). Cardiac output, obtained by the thermodilution method, was 2.45 +/- 0.48 liters/min/m2 in patients with tricuspid atresia and 2.75 +/- 0.72 liters/min/m2 in those with single ventricle. The forward flow during atrial contraction, calculated by multiplying Fa by cardiac output, was 1.32 +/- 0.35 liters/min/m2 in patients with tricuspid atresia and 1.23 +/- 0.33 liters/min/m2 in those with single ventricle. The diastolic forward flow, calculated from Fd and cardiac output, was 0.99 +/- 0.25 liter/min/m2 in patients with tricuspid atresia and 1.52 +/- 0.45 liters/min/m2 in those with single ventricle (p less than 0.005). The sum of cross-sectional areas of the right and left pulmonary arteries normalized by body surface area (PA index) was 282 +/- 85 cm2/m2 in patients with tricuspid atresia and 462 +/- 65 cm2/m2 in those with single ventricle (p less than .005). The Fa was inversely correlated with the PA index in the whole group (r = -.69) and also in the tricuspid atresia group alone (r = -.87).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

我们通过导管安装的速度探头分析了10例三尖瓣闭锁患者和10例单心室患者在Fontan手术后主肺动脉内的血流速度模式。对正向血流速度信号下方的面积进行积分,并计算心房收缩期和舒张期部分与总面积的比值(Fa和Fd)。三尖瓣闭锁患者的Fa为0.54±0.09,单心室患者为0.45±0.05(p<0.01)。通过热稀释法测得的心输出量,三尖瓣闭锁患者为2.45±0.48升/分钟/平方米,单心室患者为2.75±0.72升/分钟/平方米。通过将Fa与心输出量相乘计算得出的心房收缩期正向血流,三尖瓣闭锁患者为1.32±0.35升/分钟/平方米,单心室患者为1.23±0.33升/分钟/平方米。根据Fd和心输出量计算得出的舒张期正向血流,三尖瓣闭锁患者为0.99±0.25升/分钟/平方米,单心室患者为1.52±0.45升/分钟/平方米(p<0.005)。以体表面积标准化的左右肺动脉横截面积之和(PA指数),三尖瓣闭锁患者为282±85平方厘米/平方米,单心室患者为462±65平方厘米/平方米(p<0.005)。在整个组中,Fa与PA指数呈负相关(r = -0.69),仅在三尖瓣闭锁组中也是如此(r = -0.87)。(摘要截短至250字)

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