Tamura Ayumi, Murabayashi Masaya, Nishiya Yuki, Mizushiri Satoru, Hamaura Kiho, Ito Ryoma, Ono Shoma, Terada Akihide, Murakami Hiroshi, Tanabe Jutaro, Yanagimachi Miyuki, Tokuda Itoyo, Sawada Kaori, Ihara Kazushige, Daimon Makoto
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Department of Oral Healthcare Science, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
J Clin Med. 2022 Jun 5;11(11):3216. doi: 10.3390/jcm11113216.
Upon food digestion, the gut microbiota plays a pivotal role in energy metabolism, thus affecting the development of type 2 diabetes (DM). We aimed to examine the influence of the composition of selected nutrients consumed on the association between the gut microbiota and DM. This cross-sectional study of a general population was conducted on 1019 Japanese volunteers. Compared with non-diabetic subjects, diabetic subjects had larger proportions of the genera and but smaller proportions of the genera and in their gut microbiotas. The genera and were positively correlated with the amounts of energy ( = 0.027) and carbohydrate and fiber ( = 0.007 and = 0.010, respectively) consumed, respectively. In contrast, the genera and were not correlated with any of the selected nutrients consumed. Cluster analyses of these four genera revealed that the -dominant cluster was most negatively associated with DM, whereas the -dominant cluster was positively associated with DM (vs. the -dominant cluster; odds ratio 3.97, 95% confidence interval 1.68-9.35). These results indicate the possible involvement of nutrient factors in the association between the gut microbiota and DM. Furthermore, independent of nutrient factors, having a -dominant gut microbiota may be a risk factor for DM compared to having a -dominant gut microbiota in a general Japanese population.
食物消化过程中，肠道微生物群在能量代谢中起关键作用，进而影响2型糖尿病（DM）的发展。我们旨在研究特定营养物质的摄入组成对肠道微生物群与DM之间关联的影响。对1019名日本志愿者进行了这项针对普通人群的横断面研究。与非糖尿病受试者相比，糖尿病受试者肠道微生物群中属 和 的比例较大，但属 和 的比例较小。属 和 分别与能量摄入量（ = 0.027）以及碳水化合物和纤维摄入量（分别为 = 0.007和 = 0.010）呈正相关。相比之下，属 和 与任何选定的营养物质摄入量均无相关性。对这四个属进行聚类分析发现，以 为主的聚类与DM的负相关性最强，而以 为主的聚类与DM呈正相关（与以 为主的聚类相比；优势比3.97，95%置信区间1.68 - 9.35）。这些结果表明营养因素可能参与了肠道微生物群与DM之间的关联。此外，在一般日本人群中，与以 为主的肠道微生物群相比，以 为主的肠道微生物群可能是DM的一个风险因素，且不受营养因素影响。
