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日本一般人群中肠道微生物群与身体成分的关联：以肠道微生物群与骨骼肌为重点。

Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle.

机构信息

Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan.

Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan.

出版信息

Int J Environ Res Public Health. 2022 Jun 17;19(12):7464. doi: 10.3390/ijerph19127464.

DOI:10.3390/ijerph19127464
PMID:35742712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9224415/
Abstract

This study aimed to investigate the gut microbial genera associated with skeletal muscle mass, using a large-scale survey from the standpoint of preventing sarcopenia. A total of 848 participants were included in the analysis. The mean (SD) ages of men ( = 353) and women ( = 495) were 50.0 (12.9) years and 50.8 (12.8) years, respectively. Body composition was assessed using appendicular skeletal muscle mass/body weight (ASM/BW), ASM, and BW. Additionally, the relationship between gut microbial genera and body composition was analyzed. The means (SD) of ASM/BW were 34.9 (2.4) % in men and 29.4 (2.9) % in women. and were positively associated with ASM/BW only in men (: β = 0.0003, : β = 0.0001). However, was negatively associated with BW (β = -0.0017). was positively associated with ASM/BW (β = 0.0209) and negatively associated with BW (β = -0.0769) only in women. Our results indicate that , and , which are positively associated with ASM/BW, might help increase skeletal muscle mass. ASM/BW may clarify the relationship between gut microbiota and skeletal muscle mass without being affected by obesity or excess body fat mass.

摘要

本研究旨在从预防肌肉减少症的角度出发，通过大规模调查研究与骨骼肌量相关的肠道微生物属。共纳入 848 名参与者进行分析。男性（n=353）和女性（n=495）的平均（SD）年龄分别为 50.0（12.9）岁和 50.8（12.8）岁。采用四肢骨骼肌量/体重（ASM/BW）、ASM 和 BW 评估身体成分。此外，还分析了肠道微生物属与身体成分的关系。男性的 ASM/BW 平均值（SD）为 34.9（2.4）%，女性为 29.4（2.9）%。仅在男性中，和与 ASM/BW 呈正相关（：β=0.0003，：β=0.0001）。然而，与 BW 呈负相关（β=-0.0017）。仅在女性中，与 ASM/BW 呈正相关（β=0.0209），与 BW 呈负相关（β=-0.0769）。我们的研究结果表明，与 ASM/BW 呈正相关的、和，可能有助于增加骨骼肌量。ASM/BW 可能在不受肥胖或体脂质量影响的情况下，阐明肠道微生物群与骨骼肌量之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/9224415/db68cbca7fa5/ijerph-19-07464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/9224415/982bbefd2d3c/ijerph-19-07464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/9224415/db68cbca7fa5/ijerph-19-07464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/9224415/982bbefd2d3c/ijerph-19-07464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/9224415/db68cbca7fa5/ijerph-19-07464-g002.jpg

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Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle.

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Cell Regen. 2025-7-2

[2]
Sex-Specific Associations of Gut Microbiota Composition with Sarcopenia Defined by the Asian Working Group for Sarcopenia 2019 Consensus in Older Outpatients: Prospective Cross-Sectional Study in Japan.

Nutrients. 2025-5-21

[3]
Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population.

J Diabetes Investig. 2025-7

[4]
Gut microbiota and microbial metabolites are associated with body composition in 5-year-old children: A cross-sectional study in the Gen3G cohort.

Pediatr Obes. 2025-6

[5]
Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clinical Trial Comparing PS23 Probiotic with Heat-Treated Supplementation.

Nutrients. 2025-1-27

[6]
The Relationship Between Gut Microbiota, Muscle Mass and Physical Function in Older Individuals: A Systematic Review.

Nutrients. 2024-12-28

[7]
Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort.

Int J Environ Res Public Health. 2024-8-21

[8]
Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis.

Front Microbiol. 2024-3-25

[9]
Association between Gut Microbiota and Muscle Strength in Japanese General Population of the Iwaki Health Promotion Project.

Microorganisms. 2024-3-20

[10]
Probiotics supplementation or probiotic-fortified products on sarcopenic indices in older adults: systematic review and meta-analysis from recent randomized controlled trials.

Front Aging. 2024-2-2

本文引用的文献

[1]
Generalized bioelectric impedance-based equations underestimate body fluids in athletes.

Scand J Med Sci Sports. 2021-11

[2]
TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial.

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Sci Rep. 2021-2-25

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Int J Sports Med. 2021-6

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Gut Microbes. 2021

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Microbiota Features Associated With a High-Fat/Low-Fiber Diet in Healthy Adults.

Front Nutr. 2020-12-18

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