Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100000, China.
Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Nutrients. 2022 May 28;14(11):2274. doi: 10.3390/nu14112274.
Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.
肾细胞癌（RCC）是一种常见的泌尿系统癌症。某些天然产物对肾细胞癌的潜在治疗作用已在体内和体外得到报道，但尚未有综述对各种天然产物的作用机制进行分类和总结。在这项研究中，我们使用 PubMed 和 Google Scholar 收集和筛选了具有抗肾癌细胞作用的最新文献。这些产品的主要作用机制包括诱导细胞凋亡、抑制血管生成、抑制转移和降低耐药性。我们共研究了 30 多种天然产物，包括咖啡醇乙酸酯、厚朴酚、岩白菜素 A 和表没食子儿茶素没食子酸酯等，它们均表现出多种抗肾癌细胞的作用。总之，天然产物在肾癌中的应用可能比以前认为的更广泛，是肾细胞癌治疗的潜在候选药物。
