Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
The Department of Orthopaedics, People's Hospital of Ningxiang City, Ningxiang, Hunan Province, China.
Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20210817.
To assess the efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis (OA).
The databases such as Pubmed and Cochrane Library were searched to collect the article about Curcuma longa extract and curcumin in the treatment of OA. Then, randomized controlled trials (RCTs) were selected and their data were extracted. Finally, the RevMan5.3 was utilized for risk of bias assessment and meta-analysis, the STATA15.0 were utilized for publication bias assessment, and GRADE tool were used for the evidence quality assessment of primary outcomes.
A total of 15 RCTs involving 1621 participants were included. (1) Compared with placebo, Curcuma longa extract and curcumin (C.) can decrease the visual analog scale (VAS) and The Western Ontario and McMaster Universities (WOMAC) score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, Curcuma longa extract and curcumin are comparable with those of placebo. (2) Compared with non-steroidal anti-inflammatory drugs (NSAIDs), Curcuma longa extract and curcumin have similar effects on joint pain, function and stiffness. The incidence of adverse events in Curcuma longa extract and curcumin was lower. (3) Compared with the NSAIDs group, C.+NSAIDs can also decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, the addition of Curcuma longa extract and curcumin to NSAIDs did not increase adverse events.
Curcuma longa extract and curcumin may be a safer and effective supplement for OA patients. It is recommended to use Curcuma longa extract and curcumin supplement for OA patients for more than 12 weeks.
评估姜黄提取物和姜黄素补充剂治疗骨关节炎（OA）的疗效和安全性。
检索 Pubmed 和 Cochrane Library 等数据库，收集姜黄提取物和姜黄素治疗 OA 的文章。然后，选择随机对照试验（RCT）并提取其数据。最后，使用 RevMan5.3 进行偏倚风险评估和荟萃分析，使用 STATA15.0 进行发表偏倚评估，使用 GRADE 工具对主要结局的证据质量进行评估。
共纳入 15 项 RCT 研究，共纳入 1621 名参与者。（1）与安慰剂相比，姜黄提取物和姜黄素（C.）可降低视觉模拟评分（VAS）和西安大略和麦克马斯特大学（WOMAC）评分-疼痛、WOMAC 评分-功能和 WOMAC 评分-僵硬。在不良事件方面，姜黄提取物和姜黄素与安慰剂相当。（2）与非甾体抗炎药（NSAIDs）相比，姜黄提取物和姜黄素对关节疼痛、功能和僵硬的疗效相似。姜黄提取物和姜黄素的不良事件发生率较低。（3）与 NSAIDs 组相比，C.+NSAIDs 还可以降低 VAS 和 WOMAC 评分-疼痛、WOMAC 评分-功能和 WOMAC 评分-僵硬。在不良事件方面，姜黄提取物和姜黄素联合 NSAIDs 不会增加不良反应。
姜黄提取物和姜黄素可能是一种更安全有效的 OA 患者补充剂。建议 OA 患者使用姜黄提取物和姜黄素补充剂超过 12 周。
