Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Institute of Nutrition & Health, Qingdao University, Qingdao 266071, China.
Nutrients. 2022 May 31;14(11):2312. doi: 10.3390/nu14112312.
Findings on prenatal polyunsaturated fatty acids (PUFA) and offspring allergies have been inconsistent, and the majority of studies have focused on Western populations. This study aimed to investigate the associations between maternal erythrocyte PUFA and offspring allergies in the first 2 years in the Chinese population. We included 573 mother-infant pairs from a birth cohort. Based on the outpatient medical records, we identified the diagnosis and time of offspring allergic disease onset. We measured erythrocyte fatty acids by gas chromatography. Associations were examined using Cox regression. We found that higher maternal total PUFA levels ( = 0.80; 95% : 0.68, 0.94), especially of arachidonic acid (AA) ( = 0.79; 95% : 0.65, 0.97) and -3 PUFA ( = 0.77; 95% : 0.62, 0.97), were associated with reduced risk of offspring allergies. Similar results were found for eczema. Compared with children without a maternal allergy history, the associations of total PUFA ( = 0.028) and -6 PUFA ( = 0.013) with offspring allergies were stronger in those with a maternal allergy history. Maternal erythrocyte total PUFA, especially AA, and -3 PUFA were inversely associated with offspring allergies within 2 years of age. There was a significant interaction between maternal allergy history and maternal PUFA in offspring allergies.
研究发现，产前多不饱和脂肪酸（PUFA）与后代过敏之间的关系并不一致，且大多数研究都集中在西方人群。本研究旨在探讨中国人群中母体红细胞 PUFA 与后代过敏在 2 年内的相关性。我们纳入了来自一个出生队列的 573 对母婴。根据门诊病历，我们确定了后代过敏性疾病的诊断和发病时间。我们通过气相色谱法测量红细胞脂肪酸。使用 Cox 回归检验相关性。我们发现，母体总 PUFA 水平较高（ = 0.80；95%：0.68，0.94），尤其是花生四烯酸（AA）（ = 0.79；95%：0.65，0.97）和 -3PUFA（ = 0.77；95%：0.62，0.97），与后代过敏风险降低相关。湿疹也有类似的结果。与没有母体过敏史的儿童相比，在有母体过敏史的儿童中，总 PUFA（ = 0.028）和 -6PUFA（ = 0.013）与后代过敏的相关性更强。母体红细胞总 PUFA，尤其是 AA 和 -3PUFA，与 2 岁以下儿童的后代过敏呈负相关。母体过敏史和母体 PUFA 与后代过敏之间存在显著的交互作用。
