Faculty of Pharmacy and Nutrition, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.
Faculty of Nursing, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.
Nutrients. 2024 Aug 10;16(16):2640. doi: 10.3390/nu16162640.
Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review and meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving joint functionality and reducing pain in individuals with knee OA. A comprehensive search was conducted across PubMed, Scopus, Web of Science, and Cochrane Database up to July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met the inclusion criteria, with five included in the meta-analysis. The studies compared ESM to a placebo, evaluating outcomes based on assessment tools such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results indicated that ESM significantly reduced pain and improved functionality, with notable improvements in total WOMAC score (effect size -0.34; 95% CI: -0.56 to -0.13; < 0.001) and pain subscale (SMD -0.23; 95% CI: -0.42 to -0.04; < 0.02). The findings support ESM as a promising adjunctive treatment for knee OA, offering a safe, natural supplement to enhance quality of life. Further high-quality RCTs are needed to confirm these results and explore the long-term effects and mechanisms of ESM.
骨关节炎（OA）是一种普遍存在的退行性关节疾病，其中膝骨关节炎尤为常见且影响较大。本系统评价和荟萃分析旨在评估蛋壳膜（ESM）补充剂在改善膝骨关节炎患者关节功能和减轻疼痛方面的疗效。根据 PRISMA 指南，我们对 PubMed、Scopus、Web of Science 和 Cochrane 数据库进行了全面检索，检索截至 2024 年 7 月。共有 7 项随机对照试验（RCT）符合纳入标准，其中 5 项纳入荟萃分析。这些研究将 ESM 与安慰剂进行比较，根据 Western Ontario 和 McMaster 大学骨关节炎指数（WOMAC）、视觉模拟量表（VAS）和膝关节损伤和骨关节炎结果评分（KOOS）等评估工具评估结果。结果表明，ESM 可显著减轻疼痛并改善功能，总 WOMAC 评分（效应量-0.34；95%置信区间：-0.56 至 -0.13；<0.001）和疼痛亚量表（SMD-0.23；95%置信区间：-0.42 至 -0.04；<0.02）均有显著改善。这些发现支持 ESM 作为膝骨关节炎的一种有前途的辅助治疗方法，为提高生活质量提供了一种安全、天然的补充剂。需要进一步开展高质量 RCT 来证实这些结果，并探讨 ESM 的长期效果和作用机制。
