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MIL-101（Fe）@Ag 纳米复合材料的快速协同抗菌作用及生物安全性评价。

MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials.

机构信息

School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.

出版信息

Molecules. 2022 May 29;27(11):3497. doi: 10.3390/molecules27113497.

DOI:10.3390/molecules27113497
PMID:35684436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9182184/
Abstract

Metal-organic frameworks (MOFs), which have become popular in recent years as excellent carriers of drugs and biomimetic materials, have provided new research ideas for fighting pathogenic bacterial infections. Although various antimicrobial metal ions can be added to MOFs with physical methods, such as impregnation, to inhibit bacterial multiplication, this is inefficient and has many problems, such as an uneven distribution of antimicrobial ions in the MOF and the need for the simultaneous addition of large doses of metal ions. Here, we report on the use of MIL-101(Fe)@Ag with efficient metal-ion release and strong antimicrobial efficiency for co-sterilization. Fe-based MIL-101(Fe) was synthesized, and then Ag was uniformly introduced into the MOF by the substitution of Ag for Fe. Scanning electron microscopy, powder X-ray diffraction (PXRD) Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to investigate the synthesized MIL-101(Fe)@Ag. The characteristic peaks of MIL-101(Fe) and silver ions could be clearly seen in the PXRD pattern. Comparing the diffraction peaks of the simulated PXRD patterns clearly showed that MIL-101(Fe) was successfully constructed and silver ions were successfully loaded into MIL-101(Fe) to synthesize an MOF with a bimetallic structure, that is, the target product MIL-101(Fe)@Ag. The antibacterial mechanism of the MOF material was also investigated. MIL-101(Fe)@Ag exhibited low cytotoxicity, so it has potential applications in the biological field. Overall, MIL-101(Fe)@Ag is an easily fabricated structurally engineered nanocomposite with broad-spectrum bactericidal activity.

摘要

金属-有机骨架（MOFs）作为药物和仿生材料的优秀载体近年来备受关注，为抗致病细菌感染提供了新的研究思路。虽然可以通过物理方法（如浸渍）将各种抗菌金属离子添加到 MOF 中以抑制细菌繁殖，但这种方法效率低下，存在许多问题，例如抗菌离子在 MOF 中的分布不均匀以及需要同时添加大量金属离子。在这里，我们报告了使用 MIL-101(Fe)@Ag 进行协同杀菌，该材料具有高效的金属离子释放和强大的抗菌效率。合成了基于 Fe 的 MIL-101(Fe)，然后通过 Fe 被 Ag 取代将 Ag 均匀引入 MOF 中。使用扫描电子显微镜、粉末 X 射线衍射（PXRD）、傅里叶变换红外光谱和热重分析对合成的 MIL-101(Fe)@Ag 进行了研究。在 PXRD 图谱中可以清楚地看到 MIL-101(Fe)的特征峰和银离子。比较模拟 PXRD 图谱的衍射峰清楚地表明，成功构建了 MIL-101(Fe)并成功将银离子负载到 MIL-101(Fe)中，合成了具有双金属结构的 MOF，即目标产物 MIL-101(Fe)@Ag。还研究了 MOF 材料的抗菌机制。MIL-101(Fe)@Ag 表现出低细胞毒性，因此在生物领域具有潜在的应用。总体而言，MIL-101(Fe)@Ag 是一种易于制备的结构工程纳米复合材料，具有广谱杀菌活性。

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