用于生物医学应用的基于金属-有机骨架（MIL）的MOF材料的现状与前景
Current status and prospects of MIL-based MOF materials for biomedicine applications.
作者信息
Lin Zengqin, Liao Donghui, Jiang Chenyi, Nezamzadeh-Ejhieh Alireza, Zheng Minbin, Yuan Hui, Liu Jianqiang, Song Hailiang, Lu Chengyu
机构信息
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials Dongguan 523808 China
Chemistry Department, Shahreza Branch, Islamic Azad University Shahreza Isfahan Iran.
出版信息
RSC Med Chem. 2023 Sep 1;14(10):1914-1933. doi: 10.1039/d3md00397c. eCollection 2023 Oct 18.
This article mainly reviews the biomedicine applications of two metal-organic frameworks (MOFs), MIL-100(Fe) and MIL-101(Fe). These MOFs have advantages such as high specific surface area, adjustable pore size, and chemical stability, which make them widely used in drug delivery systems. The article first introduces the properties of these two materials and then discusses their applications in drug transport, antibacterial therapy, and cancer treatment. In cancer treatment, drug delivery systems based on MIL-100(Fe) and MIL-101(Fe) have made significant progress in chemotherapy (CT), chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy (IT), nano-enzyme therapy, and related combined therapy. Overall, these MIL-100(Fe) and MIL-101(Fe) materials have tremendous potential and diverse applications in the field of biomedicine.
本文主要综述了两种金属有机框架材料（MOFs），即MIL-100（Fe）和MIL-101（Fe）在生物医学方面的应用。这些金属有机框架材料具有比表面积高、孔径可调和化学稳定性好等优点，使其在药物递送系统中得到广泛应用。文章首先介绍了这两种材料的性质，然后讨论了它们在药物运输、抗菌治疗和癌症治疗中的应用。在癌症治疗中，基于MIL-100（Fe）和MIL-101（Fe）的药物递送系统在化疗（CT）、化学动力学疗法（CDT）、光热疗法（PTT）、光动力疗法（PDT）、免疫疗法（IT）、纳米酶疗法及相关联合疗法方面取得了显著进展。总体而言，这些MIL-100（Fe）和MIL-101（Fe）材料在生物医学领域具有巨大潜力和多样的应用。
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