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氧化石墨烯掺杂聚（3,4-乙撑二氧噻吩）-多酚氧化酶作为多巴胺传感器的一步电化学沉积研究。

Investigation of the one-step electrochemical deposition of graphene oxide-doped poly(3,4-ethylenedioxythiophene)-polyphenol oxidase as a dopamine sensor.

作者信息

Ramu P, Vimal S P, Suresh P, Sanmugam Anandhavelu, Saravanakumar U, Kumar Raju Suresh, Almansour Abdulrahman I, Arumugam Natarajan, Vikraman Dhanasekaran

机构信息

Department of Electronics and Communication Engineering, Jaya Institute of Technology Tamilnadu India

Department of Electronics and Communication Engineering, Sri Ramakrishna Engineering College Coimbatore India.

出版信息

RSC Adv. 2022 May 23;12(24):15575-15583. doi: 10.1039/d2ra00791f. eCollection 2022 May 17.

DOI:10.1039/d2ra00791f
PMID:35685176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9125988/
Abstract

In this paper, we fabricated poly(3,4-ethylenedioxythiophene) (PEDOT)-graphene oxide-polyphenol oxidase (PEDOT-GO-PPO) as a dopamine sensor. The morphology of PEDOT-GO-PPO was observed using scanning electron microscopy. Cyclic voltammetry was conducted to study the oxidation-reduction characteristics of dopamine. To optimize the pH, potential and limit of detection of dopamine, the amperometric technique was employed. The found limit of detection was 8 × 10 M, and the linear range was from 5 × 10 to 8.5 × 10 M. The Michaelis-Menten constant ( ) was calculated to be 70.34 μM, and the activation energy of the prepared electrode was 32.75 kJ mol. The electrode shows no significant change in the interference study. The modified electrode retains up to 80% of its original activity after 2 months. In the future, the biosensor can be used for the quantification of dopamine in human urine samples. The present modified electrode constitutes a tool for the electrochemical analysis of dopamine.

摘要

在本文中，我们制备了聚（3,4 - 亚乙二氧基噻吩）（PEDOT）-氧化石墨烯 - 多酚氧化酶（PEDOT - GO - PPO）作为多巴胺传感器。使用扫描电子显微镜观察了PEDOT - GO - PPO的形态。进行循环伏安法以研究多巴胺的氧化还原特性。为了优化多巴胺的pH值、电位和检测限，采用了安培技术。发现检测限为8×10⁻⁷M，线性范围为5×10⁻⁶至8.5×10⁻⁵M。米氏常数（Km）经计算为70.34μM，制备电极的活化能为32.75kJ/mol。在干扰研究中，电极显示无明显变化。修饰电极在2个月后仍保留其原始活性的80%。未来，该生物传感器可用于定量分析人尿液样本中的多巴胺。当前的修饰电极构成了一种用于多巴胺电化学分析的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/734d/9125988/a043e9f2a168/d2ra00791f-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/734d/9125988/a043e9f2a168/d2ra00791f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/734d/9125988/bff16e81b624/d2ra00791f-f1.jpg
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