Department Health Management Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Critical Care Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Endocrinol (Lausanne). 2022 May 24;13:889785. doi: 10.3389/fendo.2022.889785. eCollection 2022.
To study the association between anthropometric indexes [lipid accumulation products (LAP), visceral obesity index (VAI), triglyceride and glucose index (TyG) and waist triglyceride index (WTI)] and metabolic syndrome (MetS) in a representative sample of American adult population surveyed by National Health and Nutrition Examination Survey (NHANES).
Cross-sectional data from the NHANES were used. Participants were adults aged 18-80 y from 1996-2006. MetS were defined by the updated National Cholesterol Education Program/Adult Treatment Panel III criteria (NCEP-ATP III) for Americans. Receiver operating characteristic (ROC) curve was drawn and the areas under the curve (AUC) were used to assess the ability of these indexes in screening MetS. Statistical differences among the AUC values of these indexes were compared. The association between the anthropometric indexes and MetS was investigated using weighted multivariable-adjusted logistic regression.
560 (35.2%) males and 529 (26.4%) females were diagnosed with MetS. LAP was the strongest predictor of MetS for men (AUC=0.87, 95% CI 0.85-0.89), and also was the strongest for women [AUC=0.85, 95% confidence interval (CI) 0.83-0.86], according to the ROC curve analysis. In men, differences in AUC values between LAP and other anthropometric indicators were also significant (all <0.001). In women, there was a significant difference in AUC values between LAP and WTI (<0.001), but differences in AUC values between LAP and TyG, VAI were not significant.
The present study indicated that LAP is a better predictor in the clinical setting for identifying individuals with MetS in the American adult population.
研究在美国成人人群中，通过国家健康和营养检查调查（NHANES）调查的代表性样本中，人体测量学指标[脂质蓄积产物（LAP）、内脏肥胖指数（VAI）、甘油三酯和葡萄糖指数（TyG）以及腰围甘油三酯指数（WTI）]与代谢综合征（MetS）之间的关联。
使用来自 NHANES 的横断面数据。参与者为 1996-2006 年期间年龄在 18-80 岁的成年人。MetS 按照美国更新的国家胆固醇教育计划/成人治疗小组 III 标准（NCEP-ATP III）进行定义。绘制接收者操作特征（ROC）曲线，并使用曲线下面积（AUC）评估这些指标筛查 MetS 的能力。比较这些指标 AUC 值之间的统计学差异。使用加权多变量调整后的逻辑回归研究人体测量学指标与 MetS 之间的关系。
560 名男性（35.2%）和 529 名女性（26.4%）被诊断患有 MetS。LAP 是男性 MetS 的最强预测指标（AUC=0.87，95%CI 0.85-0.89），也是女性的最强预测指标（AUC=0.85，95%置信区间（CI）0.83-0.86），根据 ROC 曲线分析。在男性中，LAP 与其他人体测量指标之间 AUC 值的差异也具有统计学意义（均<0.001）。在女性中，LAP 与 WTI 之间的 AUC 值差异具有统计学意义（<0.001），但 LAP 与 TyG、VAI 之间的 AUC 值差异无统计学意义。
本研究表明，LAP 是美国成年人群中临床识别 MetS 个体的更好预测指标。
