Deng Jiangbei, Qin Xiao
Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
The Affiliated Changsha Central Hospital, Department of Peripheral Vascular Intervention, Hengyang Medical School, University of South China, Hengyang, China.
Front Cardiovasc Med. 2025 Jun 9;12:1524847. doi: 10.3389/fcvm.2025.1524847. eCollection 2025.
In this study, we explored the correlation between lipid accumulation product (LAP) and abdominal aortic calcification (AAC).
Data collected from 2013-2014 were obtained from the National Health and Nutrition Examination Survey (HANES) database. We utilized weighted univariate and multivariate regression analyses to assess the correlation between ln-LAP (LAP was transformed using a natural logarithm) and AAC. Further, subgroup analyses, smoothed curve fitting, and sensitivity analysis were implemented.
The study included 2,965 participants, with a mean ln-LAP index of 3.95 ± 0.83. Following adjustment for all covariates, multiple regression analyses indicated that ln-LAP, when modeled as a quadratic categorical variable, was significantly positively associated with AAC in Q3 (OR = 1.91; 95% CI: 1.20, 3.04, < 0.001) compared to the Q1, and similarly, with severe abdominal aortic calcification (SAAC) in Q4 (OR = 2.17; 95% CI: 1.08, 4.35, < 0.05). Conversely, Q2, Q3, and Q4 did not exhibit significant positive correlations with AAC scores ( > 0.05). Smoothed curve fitting revealed a nonlinear relationship between ln-LAP and AAC, characterized by an inverse U-shaped curve. Threshold effect analysis identified an inflection point at 4.21. Before this point, a marked positive correlation existed between ln-LAP and AAC (OR=1.74); beyond this point, a pronounced negative correlation was observed (OR=0.60). Subgroup analyses revealed no significant interactions regarding the correlation across age, sex, hypertension, and diabetes groups ( interaction >0.05).
This research reveals a significant inverse U-shaped correlation between LAP and the prevalence of AAC, implying that LAP could serve as a potential biomarker for evaluating AAC risk.
在本研究中，我们探讨了脂质积聚产物（LAP）与腹主动脉钙化（AAC）之间的相关性。
从国家健康与营养检查调查（HANES）数据库中获取2013 - 2014年收集的数据。我们使用加权单变量和多变量回归分析来评估自然对数转换后的LAP（ln-LAP）与AAC之间的相关性。此外，还进行了亚组分析、平滑曲线拟合和敏感性分析。
该研究纳入了2965名参与者，平均ln-LAP指数为3.95±0.83。在对所有协变量进行调整后，多元回归分析表明，当将ln-LAP建模为二次分类变量时，与第一四分位数（Q1）相比，第三四分位数（Q3）中的ln-LAP与AAC显著正相关（OR = 1.91；95%CI：1.20，3.04，P < 0.001），同样，第四四分位数（Q4）中的ln-LAP与严重腹主动脉钙化（SAAC）显著正相关（OR = 2.17；95%CI：1.08，4.35，P < 0.05）。相反，第二四分位数（Q2）、第三四分位数（Q3）和第四四分位数（Q4）与AAC评分之间未显示出显著正相关（P > 0.05）。平滑曲线拟合显示ln-LAP与AAC之间存在非线性关系，其特征为倒U形曲线。阈值效应分析确定拐点为4.21。在此点之前，ln-LAP与AAC之间存在显著正相关（OR = 1.74）；超过此点，则观察到显著负相关（OR = 0.60）。亚组分析显示，在年龄、性别、高血压和糖尿病组之间，相关性不存在显著交互作用（交互作用P > 0.05）。
本研究揭示了LAP与AAC患病率之间存在显著倒U形相关性，这意味着LAP可作为评估AAC风险的潜在生物标志物。
