对头颈癌患者与健康人群坚持地中海饮食情况的比较。

Adherence to Mediterranean diet: A comparison of patients with head and neck cancer and healthy population.

作者信息

Salvatore Benito Adriana, Valero Zanuy M Ángeles, Alarza Cano Marina, Ruiz Alonso Ana, Alda Bravo Irene, Rogero Blanco Eloísa, Maíz Jiménez María, León Sanz Miguel

机构信息

Unidad de Nutrición, Servicio de Endocrinología y Nutrición, Hospital 12 de Octubre, Madrid, España.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2019 Aug-Sep;66(7):417-424. doi: 10.1016/j.endinu.2018.12.002. Epub 2019 Jan 23.

DOI:10.1016/j.endinu.2018.12.002

PMID:30683496

Abstract

BACKGROUND AND OBJECTIVE

The traditional Mediterranean diet (MD) is associated to a lower risk of suffering multiple tumors. However, few studies have analyzed the relationship between MD and the risk of developing head and neck cancer (HNC). A case-control study comparing adherence to MD was conducted in patients diagnosed with HNC and healthy population.

PATIENTS AND METHODS

The level of adherence to MD was assessed using the 14-item MEDAS (Mediterranean Diet Adherence Screener) questionnaire, used in the PREDIMED study, in patients diagnosed with HNC at 12de Octubre Hospital in Madrid (cases) and in healthy subjects enrolled in a nearby primary health care center (controls). Adherence was stratified based on the score as low (≤7points), medium (8-9points), and high (≥10points). The odds ratio (OR) for developing HNC was estimated based on different factors.

RESULTS

A sample of 168 subjects (100 controls and 68 cases) was analyzed. Smoking (OR, 2.98 [95%CI: 1.44-6.12]; P=.003) and alcohol consumption (OR, 2.72 [95%CI: 1.39-5.33], P=.003) were strongly associated to HNC. However, medium-high adherence to MD was associated to a lower risk of developing HNC (OR, 0.48 [95%CI: 0.20-1.07], P=.052).

CONCLUSIONS

Consistent medium-high adherence to MD contributes to decrease the risk of developing HNC.

摘要

背景与目的

传统地中海饮食（MD）与患多种肿瘤的风险较低相关。然而，很少有研究分析MD与头颈癌（HNC）发生风险之间的关系。我们对诊断为HNC的患者和健康人群进行了一项比较MD依从性的病例对照研究。

患者与方法

采用PREDIMED研究中使用的包含14个条目的地中海饮食依从性筛查问卷（MEDAS），对马德里12月10日医院诊断为HNC的患者（病例组）和附近初级卫生保健中心纳入的健康受试者（对照组）进行MD依从性水平评估。根据得分将依从性分为低（≤7分）、中（8 - 9分）和高（≥10分）三个层次。基于不同因素估计发生HNC的比值比（OR）。

结果

分析了168名受试者的样本（100名对照组和68名病例组）。吸烟（OR，2.98 [95%CI：1.44 - 6.12]；P = 0.003）和饮酒（OR，2.72 [95%CI：1.39 - 5.33]，P = 0.003）与HNC密切相关。然而，中高MD依从性与较低的HNC发生风险相关（OR，0.48 [95%CI：0.20 - 1.07]，P = 0.052）。