• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

严重 COVID-19 患者的微量营养素水平与中性粒细胞-淋巴细胞比值呈负相关。

Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19.

机构信息

Clinical Nursing Department, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.

Department of Respiratory and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

出版信息

Int J Clin Pract. 2022 Jan 31;2022:6498794. doi: 10.1155/2022/6498794. eCollection 2022.

DOI:10.1155/2022/6498794
PMID:35685552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9159175/
Abstract

AIM

To explore the potential relationship between NLR and micronutrient deficiency in patients with severe COVID-19 infection.

METHODS

Sixteen patients were categorized into the mild group (mild COVID-19) and severe group (severe COVID-19) based on the guideline of the management of COVID-19. The lactate dehydrogenase (LDH); superoxide dismutase (SOD), the inflammatory markers (neutrophil lymphocyte ratio (NLR)), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), selenium (Se), iron (Fe), zinc (Zn), nickel (Ni), copper (Cu), chromium (Cr), cadmium (Cd), arsenic (As), and manganese (Mn) were measured in the blood.

RESULTS

Compared to the mild group, the NLR ( < 0.05) and the level of Se ( < 0.01), Fe ( < 0.05), and Zn ( < 0.05) were significantly decreased in the severe group. The level of Se, Fe, and Zn was significantly correlated to NLR levels. Furthermore, close positive correlation was found between NLR and severity of COVID-19.

CONCLUSION

The micronutrient deficiency in the blood is associated with NLR in the severity of COVID-19 patients.

摘要

目的

探讨严重 COVID-19 感染患者中性粒细胞与淋巴细胞比值（NLR）与微量营养素缺乏的潜在关系。

方法

根据 COVID-19 管理指南，将 16 例患者分为轻症组（轻症 COVID-19）和重症组（重症 COVID-19）。检测血乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、炎症标志物（中性粒细胞与淋巴细胞比值（NLR））、红细胞沉降率（ESR）、C 反应蛋白（CRP）、硒（Se）、铁（Fe）、锌（Zn）、镍（Ni）、铜（Cu）、铬（Cr）、镉（Cd）、砷（As）和锰（Mn）。

结果

与轻症组相比，重症组 NLR（<0.05）和 Se（<0.01）、Fe（<0.05）、Zn（<0.05）水平明显降低。Se、Fe 和 Zn 水平与 NLR 水平显著相关。此外，NLR 与 COVID-19 的严重程度呈密切正相关。

结论

COVID-19 患者血液中的微量营养素缺乏与 NLR 严重程度有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/022f4922b08e/IJCLP2022-6498794.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/316b5056d8d3/IJCLP2022-6498794.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/6a8a589eeaf3/IJCLP2022-6498794.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/022f4922b08e/IJCLP2022-6498794.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/316b5056d8d3/IJCLP2022-6498794.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/6a8a589eeaf3/IJCLP2022-6498794.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4758/9159175/022f4922b08e/IJCLP2022-6498794.003.jpg

相似文献

1
Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19.严重 COVID-19 患者的微量营养素水平与中性粒细胞-淋巴细胞比值呈负相关。
Int J Clin Pract. 2022 Jan 31;2022:6498794. doi: 10.1155/2022/6498794. eCollection 2022.
2
Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity.新型冠状病毒肺炎患者的必需微量元素、维生素和抗氧化酶活性及其与疾病严重程度的潜在关联。
Biometals. 2022 Feb;35(1):125-145. doi: 10.1007/s10534-021-00355-4. Epub 2022 Jan 7.
3
Prognostic value of neutrophil-to-lymphocyte ratio, lactate dehydrogenase, D-dimer, and computed tomography score in patients with coronavirus disease 2019.中性粒细胞与淋巴细胞比值、乳酸脱氢酶、D-二聚体和计算机断层扫描评分对新型冠状病毒肺炎患者的预后价值。
Aging (Albany NY). 2021 Sep 8;13(17):20896-20905. doi: 10.18632/aging.203501.
4
Neutrophil to lymphocytic ratio and other inflammatory markers as adverse outcome predictor in hospitalized COVID-19 patients.中性粒细胞与淋巴细胞比值和其他炎症标志物可预测住院 COVID-19 患者的不良结局。
Egypt J Immunol. 2022 Apr;29(2):57-67.
5
Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients.新冠病毒肺炎患者中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值及嗜酸性粒细胞与高分辨率计算机断层扫描严重程度评分的相关性
PLoS One. 2021 Jun 28;16(6):e0252599. doi: 10.1371/journal.pone.0252599. eCollection 2021.
6
Correlation of Low Levels of -1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients.重度新冠肺炎患者中低水平的α1抗胰蛋白酶和中性粒细胞与淋巴细胞比值升高与较高死亡率的相关性
Mediators Inflamm. 2021 Apr 28;2021:5555619. doi: 10.1155/2021/5555619. eCollection 2021.
7
Correlation of serum interleukin-6 levels and neutrophil-lymphocyte ratio in the severity of COVID-19.血清白细胞介素-6 水平与中性粒细胞-淋巴细胞比值与 COVID-19 严重程度的相关性。
F1000Res. 2023 Sep 22;12:1189. doi: 10.12688/f1000research.132157.1. eCollection 2023.
8
Cross-sectional study: Relationship between serum trace elements and hypertension.横断面研究：血清微量元素与高血压的关系。
J Trace Elem Med Biol. 2022 Jan;69:126893. doi: 10.1016/j.jtemb.2021.126893. Epub 2021 Nov 10.
9
Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.几种金属、常量和微量营养素的血药浓度与男性衰老相关内分泌紊乱之间的关系分析。
Environ Geochem Health. 2016 Jun;38(3):749-61. doi: 10.1007/s10653-015-9758-0. Epub 2015 Aug 9.
10
Relationship between neutrophil-lymphocyte, platelet-lymphocyte ratio and disease activity in rheumatoid arthritis treated with rituximab.利妥昔单抗治疗的类风湿关节炎中中性粒细胞与淋巴细胞、血小板与淋巴细胞比值与疾病活动度的关系
Int J Rheum Dis. 2018 Dec;21(12):2122-2127. doi: 10.1111/1756-185X.13400. Epub 2018 Oct 18.

引用本文的文献

1
Association of zinc deficiency and clinical symptoms, inflammatory markers, severity of COVID-19 in hospitalized children.住院儿童锌缺乏与临床症状、炎症标志物、新冠病毒疾病严重程度的关联
Front Nutr. 2025 Mar 25;12:1566505. doi: 10.3389/fnut.2025.1566505. eCollection 2025.
2
A cross-sectional study of laboratory parameters 5-6 months after the first COVID-19 infection.一项关于首次感染新冠病毒5至6个月后实验室参数的横断面研究。
Heliyon. 2025 Feb 10;11(4):e42535. doi: 10.1016/j.heliyon.2025.e42535. eCollection 2025 Feb 28.
3
Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population.

本文引用的文献

1
Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS.微量营养素补充对患有严重急性呼吸窘迫综合征的危重症 COVID-19 患者的临床意义。
Nutrients. 2021 Jun 20;13(6):2113. doi: 10.3390/nu13062113.
2
Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients.新冠病毒肺炎患者中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值及嗜酸性粒细胞与高分辨率计算机断层扫描严重程度评分的相关性
PLoS One. 2021 Jun 28;16(6):e0252599. doi: 10.1371/journal.pone.0252599. eCollection 2021.
3
Trace Elements as Immunoregulators in SARS-CoV-2 and Other Viral Infections.
多种重金属暴露与中国中老年人群全身免疫炎症的关系。
BMC Public Health. 2024 Apr 29;24(1):1192. doi: 10.1186/s12889-024-18638-z.
4
Zinc Deficiency And sTNF-RII Are Associated With Worse COVID-19 Outcomes.锌缺乏和可溶性肿瘤坏死因子受体 II 与 COVID-19 不良结局相关。
J Nutr. 2024 May;154(5):1588-1595. doi: 10.1016/j.tjnut.2023.11.026. Epub 2023 Dec 2.
5
Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters.新型冠状病毒肺炎患者微量元素和金属硫蛋白状态的演变：与临床、生化及炎症参数的关系
Metabolites. 2023 Aug 9;13(8):931. doi: 10.3390/metabo13080931.
6
Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.新型冠状病毒感染患者血清中的硒水平：系统评价和荟萃分析。
J Nutr Sci. 2023 Jul 26;12:e86. doi: 10.1017/jns.2023.69. eCollection 2023.
7
Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.硒补充剂能预防 COVID-19 吗？对现有研究的全面综述。
Molecules. 2023 May 16;28(10):4130. doi: 10.3390/molecules28104130.
8
Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?硒、中风和感染：三重关系；我们的立场在哪里，我们的方向在哪里？
Nutrients. 2023 Mar 15;15(6):1405. doi: 10.3390/nu15061405.
9
Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.硒状态、硒蛋白与 COVID-19 及其他炎症性疾病的关系：批判性综述。
J Trace Elem Med Biol. 2023 Jan;75:127099. doi: 10.1016/j.jtemb.2022.127099. Epub 2022 Nov 3.
10
Effect of Omega-3 fatty acids supplementation on serum level of C-reactive protein in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.ω-3 脂肪酸补充剂对 COVID-19 患者血清 C 反应蛋白水平的影响：随机对照试验的系统评价和荟萃分析。
J Transl Med. 2022 Sep 5;20(1):401. doi: 10.1186/s12967-022-03604-3.
微量元素作为新冠病毒及其他病毒感染中的免疫调节剂
Indian J Clin Biochem. 2021 Oct;36(4):416-426. doi: 10.1007/s12291-021-00961-6. Epub 2021 Feb 12.
4
The Strategy of Boosting the Immune System Under the COVID-19 Pandemic.新冠疫情下增强免疫系统的策略
Front Vet Sci. 2021 Jan 8;7:570748. doi: 10.3389/fvets.2020.570748. eCollection 2020.
5
Neutrophils and COVID-19: The road so far.中性粒细胞与2019冠状病毒病：迄今为止的进展
Int Immunopharmacol. 2021 Jan;90:107233. doi: 10.1016/j.intimp.2020.107233. Epub 2020 Nov 30.
6
Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to Coronavirus.植物源产品和植物化学物质作为提高对冠状病毒耐受性的候选策略。
Front Vet Sci. 2020 Oct 20;7:573159. doi: 10.3389/fvets.2020.573159. eCollection 2020.
7
A meta-analysis of SARS-CoV-2 patients identifies the combinatorial significance of D-dimer, C-reactive protein, lymphocyte, and neutrophil values as a predictor of disease severity.一项关于 SARS-CoV-2 患者的荟萃分析确定了 D-二聚体、C 反应蛋白、淋巴细胞和中性粒细胞值的组合意义，作为疾病严重程度的预测指标。
Int J Lab Hematol. 2021 Apr;43(2):324-328. doi: 10.1111/ijlh.13354. Epub 2020 Oct 3.
8
Anemia is associated with severe coronavirus disease 2019 (COVID-19) infection.贫血与2019年冠状病毒病（COVID-19）严重感染相关。
Transfus Apher Sci. 2020 Dec;59(6):102926. doi: 10.1016/j.transci.2020.102926. Epub 2020 Aug 28.
9
Neutrophil/lymphocyte ratio-A marker of COVID-19 pneumonia severity.中性粒细胞/淋巴细胞比值-COVID-19 肺炎严重程度的标志物。
Int J Clin Pract. 2021 Apr;75(4):e13698. doi: 10.1111/ijcp.13698. Epub 2021 Jan 12.
10
Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis.乳酸脱氢酶水平可预测 2019 冠状病毒病（COVID-19）的严重程度和死亡率：一项汇总分析。
Am J Emerg Med. 2020 Sep;38(9):1722-1726. doi: 10.1016/j.ajem.2020.05.073. Epub 2020 May 27.