严重 COVID-19 患者的微量营养素水平与中性粒细胞-淋巴细胞比值呈负相关。
Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19.
机构信息
Clinical Nursing Department, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Respiratory and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
出版信息
Int J Clin Pract. 2022 Jan 31;2022:6498794. doi: 10.1155/2022/6498794. eCollection 2022.
AIM
To explore the potential relationship between NLR and micronutrient deficiency in patients with severe COVID-19 infection.
METHODS
Sixteen patients were categorized into the mild group (mild COVID-19) and severe group (severe COVID-19) based on the guideline of the management of COVID-19. The lactate dehydrogenase (LDH); superoxide dismutase (SOD), the inflammatory markers (neutrophil lymphocyte ratio (NLR)), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), selenium (Se), iron (Fe), zinc (Zn), nickel (Ni), copper (Cu), chromium (Cr), cadmium (Cd), arsenic (As), and manganese (Mn) were measured in the blood.
RESULTS
Compared to the mild group, the NLR ( < 0.05) and the level of Se ( < 0.01), Fe ( < 0.05), and Zn ( < 0.05) were significantly decreased in the severe group. The level of Se, Fe, and Zn was significantly correlated to NLR levels. Furthermore, close positive correlation was found between NLR and severity of COVID-19.
CONCLUSION
The micronutrient deficiency in the blood is associated with NLR in the severity of COVID-19 patients.
目的
探讨严重 COVID-19 感染患者中性粒细胞与淋巴细胞比值（NLR）与微量营养素缺乏的潜在关系。
方法
根据 COVID-19 管理指南，将 16 例患者分为轻症组（轻症 COVID-19）和重症组（重症 COVID-19）。检测血乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、炎症标志物（中性粒细胞与淋巴细胞比值（NLR））、红细胞沉降率（ESR）、C 反应蛋白（CRP）、硒（Se）、铁（Fe）、锌（Zn）、镍（Ni）、铜（Cu）、铬（Cr）、镉（Cd）、砷（As）和锰（Mn）。
结果
与轻症组相比，重症组 NLR（<0.05）和 Se（<0.01）、Fe（<0.05）、Zn（<0.05）水平明显降低。Se、Fe 和 Zn 水平与 NLR 水平显著相关。此外，NLR 与 COVID-19 的严重程度呈密切正相关。
结论
COVID-19 患者血液中的微量营养素缺乏与 NLR 严重程度有关。
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