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来自妊娠相关结核免疫变化（PRACHITi）研究的孕妇结核病转录分析。

Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study.

机构信息

Center for Global Health, Weill Cornell Medicine, New York, New York, USA.

Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil.

出版信息

Clin Infect Dis. 2022 Dec 19;75(12):2239-2242. doi: 10.1093/cid/ciac437.

DOI:10.1093/cid/ciac437
PMID:35686302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9761891/
Abstract

A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).

摘要

一种新的结核病（TB）诊断试剂盒检测方法，可在全血中检测到 3 个 TB 基因特征，但在印度患有母婴 TB 疾病的女性中诊断效果不佳（曲线下面积[AUC] = 0.72）。在一组孕妇队列中，我们确定了一组新的用于 TB 诊断的基因集（AUC = 0.97）和一组用于 TB 进展的基因集（AUC = 0.96）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a005/9761891/cefbf1e8a24e/ciac437f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a005/9761891/cefbf1e8a24e/ciac437f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a005/9761891/cefbf1e8a24e/ciac437f1.jpg

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本文引用的文献

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A novel blood-based assay for treatment monitoring of tuberculosis.一种新型基于血液的结核病治疗监测检测方法。
BMC Res Notes. 2021 Jun 30;14(1):247. doi: 10.1186/s13104-021-05663-z.
2
Effect of pregnancy and HIV infection on detection of latent TB infection by Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube assay among women living in a high TB and HIV burden setting.在高结核和艾滋病毒负担环境中，妊娠和艾滋病毒感染对结核菌素皮肤试验和 QuantiFERON-TB Gold In-Tube 检测潜伏性结核感染的影响。
Int J Infect Dis. 2020 Dec;101:235-242. doi: 10.1016/j.ijid.2020.09.1452. Epub 2020 Oct 9.
3
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response.
低收入和中等收入国家孕期及产后结核病的临床表现与检测：一项系统评价和荟萃分析
PLOS Glob Public Health. 2023 Aug 23;3(8):e0002222. doi: 10.1371/journal.pgph.0002222. eCollection 2023.
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A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction.一项关于全血基因表达在结核-糖尿病相互作用中的多中心前瞻性队列研究。
Sci Rep. 2023 May 12;13(1):7769. doi: 10.1038/s41598-023-34847-9.
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Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities.孕妇中的结核感染：当前实践与研究重点
Pathogens. 2022 Dec 6;11(12):1481. doi: 10.3390/pathogens11121481.
RISK6，一种结核病风险、诊断和治疗反应的 6 基因转录组特征。
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