孕妇中的结核感染：当前实践与研究重点
Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities.
作者信息
Mathad Jyoti S, Yadav Sharan, Vaidyanathan Arthi, Gupta Amita, LaCourse Sylvia M
机构信息
Department of Medicine, Center for Global Health, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10065, USA.
Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.
出版信息
Pathogens. 2022 Dec 6;11(12):1481. doi: 10.3390/pathogens11121481.
Abstract
Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.
摘要
与生命中的其他任何时期相比，女性在怀孕后的前90天内患结核病的可能性要高得多。怀孕是否会增加从结核感染（TBI）进展为结核病的风险尚不清楚，这是一个正在积极研究的领域。在本综述中，我们讨论了孕期结核病和TBI的流行病学、TBI诊断以及孕期患病率。我们还回顾了TBI治疗，并强调了研究重点，如短程结核病预防方案、耐多药结核病预防，以及针对孕妇和产后人群的安全性、耐受性和药代动力学的其他特殊考虑因素。
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