Santucci B, Cristaudo A, Cannistraci C, Picardo M
Contact Dermatitis. 1987 Feb;16(2):93-5. doi: 10.1111/j.1600-0536.1987.tb01386.x.
2 groups of patients (1200 and 1500 respectively) were patch tested with different concentrations of perfume mix and fragrance raw materials. The study was to evaluate the incidence of contact dermatitis to fragrances in Roma, Italy, and the influence of limited variations in fragrance and perfume mix concentrations on patch test responses. The results showed that a decrease in the perfume mix concentration from 16% to 8% correlated with a decrease in the % of positive patients (from 5.2% to 3.6%). Variations in the concentration of fragrance raw materials did not influence the % of positive reactions in the 2 groups. The perfume mixture at 16% or 8% gave some positive results, without a corresponding reaction to any of the constituents, that were not related to an excited skin syndrome.
两组患者（分别为1200例和1500例）用不同浓度的香水混合物和香料原料进行了斑贴试验。该研究旨在评估意大利罗马对香料发生接触性皮炎的发生率，以及香料和香水混合物浓度的有限变化对斑贴试验反应的影响。结果表明，香水混合物浓度从16%降至8%与阳性患者百分比的下降相关（从5.2%降至3.6%）。香料原料浓度的变化未影响两组的阳性反应百分比。16%或8%的香水混合物产生了一些阳性结果，对任何成分均无相应反应，这些结果与皮肤兴奋综合征无关。
