口服避孕药对月经稀发青春期女性月经周期激素水平的影响。

The effect of oral contraceptives on hormone profiles of oligomenorrheic adolescent cycles.

作者信息

Siegberg R, Nilsson C G, Stenman U H, Widholm O

出版信息

Contraception. 1987 Jan;35(1):29-40. doi: 10.1016/0010-7824(87)90048-5.

Abstract

Nineteen adolescent girls with oligomenorrhea were studied to evaluate the effect of oral contraceptives (OCs) on hormone profiles, and 19 adolescent girls with regular menstruations served as control subjects. Serum levels of luteinizing hormone and androgens were higher in the oligomenorrheic girls than in the regularly menstruating girls. During the OC treatment the hormone levels of the oligomenorrheic girls decreased, approaching those of the control subjects. During follow-up cycle immediately after stopping the OCs the hormone levels increased rapidly, but in the oligomenorrheic girls the levels of luteinizing hormone, androstenedione, total and free testosterone were still significantly lower at the end of the post-treatment cycle than during the luteal phase of the pre-treatment cycle. The frequency of ovulation decreased to the same magnitude as reported in adults after discontinuation of OCs. No post-pill amenorrhea existed in either group of adolescents.

摘要

对19名月经过少的青春期女孩进行研究，以评估口服避孕药（OCs）对激素水平的影响，19名月经周期规律的青春期女孩作为对照。月经过少女孩的血清促黄体生成素和雄激素水平高于月经周期规律的女孩。在OC治疗期间，月经过少女孩的激素水平下降，接近对照组。在停止服用OCs后的随访周期中，激素水平迅速上升，但月经过少女孩在治疗后周期结束时促黄体生成素、雄烯二酮、总睾酮和游离睾酮水平仍显著低于治疗前周期的黄体期。停用OCs后，排卵频率下降幅度与成人报道的相同。两组青少年均未出现停药后闭经。