Schoessler J P, Orsborn G N
Curr Eye Res. 1987 Feb;6(2):301-6. doi: 10.3109/02713688709025182.
An analysis of the corneal endothelium of a 23 year old female who had never worn contact lenses but who had unilateral ptosis, showed marked endothelial pleomorphism of the cornea underneath the closed lid. Since corneal hypoxia has been shown to produce corneal endothelial polymegethism in contact lens wearers, and since hypoxic conditions exist under the closed lid, it is reasonable to assume that the polymegethous endothelial changes which occur with aging are a result of chronic corneal exposure to hypoxic conditions under the closed lid during sleep. Corneal hypoxia is apparently not the cause of declining endothelial cell density with age.
对一名23岁从未佩戴过隐形眼镜但患有单侧上睑下垂的女性的角膜内皮进行分析，结果显示闭眼下方角膜存在明显的内皮多形性。由于角膜缺氧已被证明会在隐形眼镜佩戴者中导致角膜内皮大小不均，且由于闭眼时存在缺氧情况，因此有理由假设随着年龄增长出现的内皮大小不均变化是睡眠期间角膜在闭眼状态下长期暴露于缺氧环境的结果。角膜缺氧显然不是内皮细胞密度随年龄下降的原因。
