Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Clin Respir J. 2022 Jul;16(7):487-496. doi: 10.1111/crj.13514. Epub 2022 Jun 10.
To present a review on the pathogenesis, risk factor and treatment of chronic obstructive pulmonary disease complicated with osteoporosis and provide new ideas for the diagnosis and treatment.
A systematic search is carried out using keywords as chronic obstructive pulmonary disease, osteoporosis, risk factors, and pulmonary rehabilitation.
Patients with chronic obstructive pulmonary disease have a high prevalence of osteoporosis and a high risk of fracture. The mechanisms of osteoporosis in COPD patients are associated with general risk factors, such as smoking, reduced physical activity, low weight, and disease-specific risk factors, such as systemic inflammatory, Vitamin D deficiency, use of glucocorticoid, anemia, hypoxemia, and hypercapnia. The treatment of osteoporosis in COPD emphasizes comprehensive intervention, which mainly include basic treatment and anti-osteoporosis drugs. Noticeably, pulmonary rehabilitation program is an important part of treatment.
This work summarizes the pathogenesis, risk factor, prevention, and treatment of chronic obstructive pulmonary disease complicated with osteoporosis, and the latest progress of studies on chronic obstructive pulmonary disease and osteoporosis is discussed.
介绍慢性阻塞性肺疾病合并骨质疏松症的发病机制、危险因素和治疗方法，为其诊断和治疗提供新思路。
使用关键词“慢性阻塞性肺疾病、骨质疏松症、危险因素和肺康复”进行系统检索。
慢性阻塞性肺疾病患者骨质疏松症患病率高，骨折风险高。COPD 患者骨质疏松症的发病机制与一般危险因素有关，如吸烟、体力活动减少、体重减轻，以及与疾病相关的特定危险因素，如全身炎症、维生素 D 缺乏、糖皮质激素的应用、贫血、低氧血症和高碳酸血症。COPD 合并骨质疏松症的治疗强调综合干预，主要包括基础治疗和抗骨质疏松药物。值得注意的是，肺康复计划是治疗的重要组成部分。
本文总结了慢性阻塞性肺疾病合并骨质疏松症的发病机制、危险因素、预防和治疗，并讨论了慢性阻塞性肺疾病和骨质疏松症的最新研究进展。
