Department for Synthesis of Macromolecules, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Austrian Institute of Technology GmbH, Biosensor Technologies, Tulln, 3430, Austria.
Macromol Rapid Commun. 2023 Aug;44(16):e2200332. doi: 10.1002/marc.202200332. Epub 2022 Jul 1.
Bioderived polymers are one of many current research areas that promise a sustainable future. Due to their unique properties, the bioderived polymer polydopamine has been in the spotlight over the last decades. Its ability to adhere to virtually any surface and its stability over a wide pH range as well as in several organic solvents make it a suitable candidate for various applications like coatings and biosensors. However, strong light absorption over a broad range of wavelengths and high quenching efficiency limit its uses. Therefore, new bioderived polymers with similar features to polydopamine but without fluorescence quenching properties are highly desirable. Herein, the electropolymerization of a bioderived analog of dopamine, 3-amino-l-tyrosine, is demonstrated. The resulting polymer, poly(amino-l-tyrosine), exhibits several characteristics complementary to or even exceeding those of polydopamine and its analog, polynorepinephrine, rendering poly(amino-l-tyrosine) attractive for the development of sensors and photoactive devices. Cyclic voltammetry, spectro-electrochemistry, and electrochemical quartz crystal microbalance measurements are applied to study the electrodeposition of this material, and the resulting films are compared to polydopamine and polynorepinephrine. Impedance spectroscopy reveals increased ion permeability of poly(amino-l-tyrosine) compared to polydopamine and polynorepinephrine. Moreover, the reduced fluorescence quenching of poly(amino-l-tyrosine) supports its use as coating for biosensors and organic semiconductors.
生物衍生聚合物是许多当前研究领域之一，有望实现可持续的未来。由于其独特的性质，生物衍生聚合物聚多巴胺在过去几十年中备受关注。它几乎可以附着在任何表面上的能力，以及在宽 pH 范围和几种有机溶剂中的稳定性，使其成为各种应用的合适候选物，如涂层和生物传感器。然而，其广泛波长范围内的强吸收和高猝灭效率限制了其用途。因此，具有类似于聚多巴胺的类似特性但没有荧光猝灭性质的新型生物衍生聚合物是非常需要的。在此，展示了多巴胺的生物衍生类似物 3-氨基-L-酪氨酸的电聚合。所得聚合物聚（氨基-L-酪氨酸）表现出几种与聚多巴胺及其类似物聚去甲肾上腺素互补的特性，甚至超过了它们，使得聚（氨基-L-酪氨酸）成为开发传感器和光活性器件的有吸引力的材料。循环伏安法、光谱电化学和电化学石英晶体微天平测量被应用于研究该材料的电沉积，并且将所得薄膜与聚多巴胺和聚去甲肾上腺素进行了比较。阻抗谱表明，与聚多巴胺和聚去甲肾上腺素相比，聚（氨基-L-酪氨酸）的离子渗透性增加。此外，聚（氨基-L-酪氨酸）荧光猝灭的减少支持其作为生物传感器和有机半导体的涂层的用途。
