Hellier M D, Bhat P, Albert J, Baker S J
Gut. 1977 Jun;18(6):480-3. doi: 10.1136/gut.18.6.480.
Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorption from the free amino acid or dipeptide solutions showed no significant difference between the groups and was similar to absorption from normal saline. These results differ from data obtained in normal English subjects where at these concentrations significant stimulation of sodium and water absorption was seen. In a proportion of subjects in both groups net secretion was observed. However, no correlation was seen between mucosal histology or luminal bacteriology and sodium or water movement. These findings in patients with chronic tropical sprue are similar to findings in normal Indians and suggest that jejunal handling of sodium and water is abnormal when compared with normal English subjects, but that the mucosa is not in a secretory phase as seen in certain other diarrhoeal states or in the acute early phase of sprue.
对10名正常印度人和11名慢性热带口炎性腹泻患者的空肠钠和水吸收情况进行了研究。研究了生理盐水以及含氨基酸和二肽的溶液。在两组中，从生理盐水中的钠和水吸收都很少。游离氨基酸或二肽溶液的平均水和钠吸收在两组之间没有显著差异，且与生理盐水的吸收相似。这些结果与在正常英国受试者中获得的数据不同，在这些浓度下，正常英国受试者的钠和水吸收有显著刺激。在两组的部分受试者中观察到了净分泌。然而，黏膜组织学或腔内细菌学与钠或水的移动之间没有相关性。慢性热带口炎性腹泻患者的这些发现与正常印度人的发现相似，表明与正常英国受试者相比，空肠对钠和水的处理是异常的，但黏膜并不处于某些其他腹泻状态或口炎性腹泻急性早期所见的分泌阶段。
