TMEM132 家族基因在发育中的小鼠神经系统中的差异表达。
Differential expression of the Tmem132 family genes in the developing mouse nervous system.
机构信息
Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China; Department of Biology, Eberly College of Science and Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, USA.
Department of Biology, Eberly College of Science and Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, USA.
出版信息
Gene Expr Patterns. 2022 Sep;45:119257. doi: 10.1016/j.gep.2022.119257. Epub 2022 Jun 8.
Abstract
The family of novel transmembrane proteins (TMEM) 132 have been associated with multiple neurological disorders and cancers in humans, but have hardly been studied in vivo. Here we report the expression patterns of the five Tmem132 genes (a, b, c, d and e) in developing mouse nervous system with RNA in situ hybridization in wholemount embryos and tissue sections. Our results reveal differential and partially overlapping expression of multiple Tmem132 family members in both the central and peripheral nervous system, suggesting potential partial redundancy among them.
摘要
新型跨膜蛋白 (TMEM) 132 家族与人类的多种神经退行性疾病和癌症有关，但在体内几乎没有研究过。在这里，我们利用全胚胎原位杂交和组织切片 RNA 原位杂交技术，报告了五个 Tmem132 基因 (a、b、c、d 和 e) 在发育中的小鼠神经系统中的表达模式。我们的结果显示，多个 Tmem132 家族成员在中枢和外周神经系统中的表达存在差异且部分重叠，这表明它们之间存在潜在的部分冗余。
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