Hanlon D P, Ferm V H
Environ Res. 1987 Apr;42(2):546-52. doi: 10.1016/s0013-9351(87)80221-9.
We determined the concentration and chemical status of arsenic in the placentas of hamsters following continuous exposure via the osmotic minipump to minimally and frankly teratogenic doses of arsenate. Close to 70% of the placental arsenic is bound to macromolecules, two-thirds of which is dialyzable. The remaining 30% of arsenic consists of low molecular weight species, predominantly inorganic arsenic. This mix is the same for minimally teratogenic and frankly teratogenic doses of arsenate.
我们通过渗透微型泵持续给仓鼠注射最低致畸剂量和明显致畸剂量的砷酸盐，测定了仓鼠胎盘内砷的浓度和化学状态。胎盘内近70%的砷与大分子结合，其中三分之二可透析。其余30%的砷由低分子量物质组成，主要是无机砷。最低致畸剂量和明显致畸剂量的砷酸盐产生的这种混合状态相同。
