Ferm V H
Environ Health Perspect. 1977 Aug;19:215-7. doi: 10.1289/ehp.7719215.
Sodium arsenate induces developmental malformations in a variety of experimental animals. In the golden hamster, the intravenous (or intraperitoneal) administration of 20 mg/kg of sodium arsenate during day 8 to 9 of gestation induces a rather specific spectrum of congenital malformations. This period corresponds to the period of very rapid differentiation and major organogenesis in this animal. The spectrum of defects produced by arsenate in the hamster includes exencephaly, encephaloceles, skeletal defects, and malformations of the genito-urinary system. This teratogenic effect can be significantly reduced by the simultaneous administration of selenium. Recent studies in this laboratory have demonstrated the permeability of the placenta to 74As during the early critical stages of embryogenesis and the distribution of this isotope in maternal, placental and embryonic tissues. We have also recently demonstrated the marked potentiation of the teratogenic effect of sodium arsenate by subjecting the mothers to short periods of hyperthermia immediately following the administration of subteratogenic or minimal teratogenic levels of arsenate.
砷酸钠可在多种实验动物中诱发发育畸形。在金黄仓鼠中，于妊娠第8至9天静脉内（或腹腔内）给予20毫克/千克的砷酸钠会诱发相当特定的一系列先天性畸形。此时期与该动物非常快速的分化和主要器官发生期相对应。砷酸盐在仓鼠中产生的缺陷谱包括无脑畸形、脑膨出、骨骼缺陷以及泌尿生殖系统畸形。同时给予硒可显著降低这种致畸作用。本实验室最近的研究表明，在胚胎发育的早期关键阶段，胎盘对74As具有通透性，并且该同位素在母体、胎盘和胚胎组织中的分布情况。我们最近还证明，在给予低于致畸或最低致畸水平的砷酸盐后，使母体短时间处于高温状态，会显著增强砷酸钠的致畸作用。
