Silva Julianne Coelho, Cetira Filho Edson Luiz, Silva Paulo Goberlânio de Barros, Costa Fábio Wildson Gurgel, Saboia Vicente de Paulo Aragão
Department of Restorative Dentistry, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.
Restor Dent Endod. 2022 May 6;47(2):e23. doi: 10.5395/rde.2022.47.e23. eCollection 2022 May.
The aim of this investigation was to evaluate the effectiveness of collagen cross-linking agents (CCLAs) used in combination with the adhesive technique in restorative procedures.
In this systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. An electronic search was performed using PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and DOSS, up to October 2020. The gray literature was also researched. Only randomized clinical trials were selected.
The selection process yielded 3 studies from the 838 retrieved. The addition of CCLAs in the retention of restorations increased the number of events. The postoperative sensitivity scores and marginal adaptation scores showed no significant difference between the CCLA and control groups, and the marginal pigmentation scores showed a significant increase in the CCLA group. There were no caries events in any group throughout the evaluation period.
This systematic review showed that there is no clinical efficacy to justify the use of CCLAs in the protocols performed.
本研究旨在评估胶原交联剂（CCLAs）与粘结技术联合用于修复治疗的有效性。
在本系统评价中，作者遵循系统评价和Meta分析的首选报告项目清单。截至2020年10月，使用PubMed、Scopus、科学网、Cochrane图书馆、LILACS和DOSS进行电子检索。还检索了灰色文献。仅选择随机临床试验。
从检索到的838项研究中筛选出3项研究。添加CCLAs可增加修复体固位的事件数量。术后敏感评分和边缘适应性评分在CCLA组和对照组之间无显著差异，边缘色素沉着评分在CCLA组显著增加。在整个评估期内，任何组均未发生龋病事件。
本系统评价表明，在已实施的方案中使用CCLAs没有临床疗效依据。
