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可溶性 Klotho 与糖尿病肾病早期的关系：系统评价和荟萃分析。

Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

机构信息

Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Department of Endocrinology and Metabolism, Fourth People's Hospital of Shenyang, Shenyang, China.

出版信息

Front Endocrinol (Lausanne). 2022 May 27;13:902765. doi: 10.3389/fendo.2022.902765. eCollection 2022.

DOI:10.3389/fendo.2022.902765
PMID:35692408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9186104/
Abstract

BACKGROUND

Diabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those without DN, in the early stage of patients with DN with normal renal function and albuminuria, the change in sKlotho is still controversial.

AIM

This meta-analysis was conducted to statistically evaluate sKlotho levels in patients with DN.

METHODS

We searched the following electronic databases: Web of Science, Embase, PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI). The following search terms were used for the title or abstract: "diabetic kidney disease", "diabetic nephropathy", OR "DN" in combination with "Klotho". The meta-analysis results were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).

RESULTS

Fourteen articles were included in the meta-analysis. In our meta-analysis, we found that the sKlotho level in patients with DN was significantly lower than that in patients without DN (SMD: -1.52, 95% CI [-2.24, -0.80]), and it was also significantly lower in the early stage of DN (SMD: -1.65, 95% CI [-2.60, -0.70]).

CONCLUSIONS

This systematic review was the first to evaluate the relationship between sKlotho levels and DN. The sKlotho level was significantly lower in the early stages of DN, indicating that sKlotho might be a new biomarker of DN in the future.

摘要

背景

糖尿病肾病（DN）是糖尿病患者长期高血糖引起的慢性微血管并发症，也是终末期肾病的重要原因。虽然一些研究表明，DN 患者的可溶性 Klotho（sKlotho）水平低于无 DN 患者，但在肾功能正常和白蛋白尿的 DN 早期患者中，sKlotho 的变化仍存在争议。

目的

本荟萃分析旨在对 DN 患者的 sKlotho 水平进行统计学评估。

方法

我们检索了以下电子数据库：Web of Science、Embase、PubMed、Google Scholar 和中国知网（CNKI）。使用以下标题或摘要搜索词：“糖尿病肾病”、“糖尿病肾病”或“DN”与“Klotho”相结合。荟萃分析结果以标准化均数差值（SMD）及其相应的 95%置信区间（CI）表示。

结果

纳入了 14 篇文章进行荟萃分析。在我们的荟萃分析中，我们发现 DN 患者的 sKlotho 水平明显低于无 DN 患者（SMD：-1.52，95%CI [-2.24，-0.80]），DN 早期患者的 sKlotho 水平也明显较低（SMD：-1.65，95%CI [-2.60，-0.70]）。

结论

这是首次评估 sKlotho 水平与 DN 之间关系的系统评价。DN 早期 sKlotho 水平显著降低，表明 sKlotho 可能成为未来 DN 的一种新的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/8e35566938aa/fendo-13-902765-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/916816487164/fendo-13-902765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/39c616f298cd/fendo-13-902765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/5023952f7c03/fendo-13-902765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/f9809d75cbca/fendo-13-902765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/8e35566938aa/fendo-13-902765-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/916816487164/fendo-13-902765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/39c616f298cd/fendo-13-902765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/5023952f7c03/fendo-13-902765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/f9809d75cbca/fendo-13-902765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b37/9186104/8e35566938aa/fendo-13-902765-g005.jpg

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