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成纤维细胞生长因子 21、Klotho 与糖尿病视网膜病变的关系：一项荟萃分析。

Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: a meta-analysis.

机构信息

Department of Ophthalmology, Fourth People's Hospital of Shenyang, Shenyang, China.

Department of Ophthalmology, Fourth Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Front Endocrinol (Lausanne). 2024 Aug 27;15:1390035. doi: 10.3389/fendo.2024.1390035. eCollection 2024.

DOI:10.3389/fendo.2024.1390035
PMID:39257905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384578/
Abstract

BACKGROUND

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Research has identified a close relationship between fibroblast growth factor 21 (FGF21) and DR. FGF21 is a member of the FGF subfamily, which is activated by the Klotho coenzyme involved in the occurrence of DR. However, the association between FGF21, Klotho, and DR remains controversial.

AIM

To assess FGF21 and Klotho levels in patients with DR.

METHODS

A literature search of the Web of Science, Wiley Online Library, PubMed, China National Knowledge Infrastructure and Wanfang databases was performed. The title or abstract search terms "diabetic retinopathy" and "DR" were used in combination with "fibroblast growth factor 21", "FGF21", and "Klotho". Meta-analysis results are presented as standardized mean difference (SMD) with corresponding 95% confidence interval (CI).

RESULTS

Fifteen studies were included in this meta-analysis. FGF21 levels in patients with DR were significantly higher than in non-DR patients with diabetes (SMD: 2.12, 95% CI [1.40, 2.84]). Klotho levels in patients with DR were significantly lower than in non-DR patients with diabetes (SMD: -0.63, 95% CI [-1.22, - 0.04]).

CONCLUSIONS

This systematic review is the first to evaluate the relationship between FGF21, Klotho levels, and DR. FGF21 levels were significantly higher in patients with DR. Fully elucidating the role of FGF21 will significantly contribute to the treatment of DR.

摘要

背景

糖尿病视网膜病变（DR）是糖尿病的一种严重的微血管并发症。研究发现，成纤维细胞生长因子 21（FGF21）与 DR 密切相关。FGF21 是 FGF 亚家族的一员，其活性由参与 DR 发生的 Klotho 辅酶激活。然而，FGF21、Klotho 与 DR 之间的关联仍存在争议。

目的

评估 DR 患者的 FGF21 和 Klotho 水平。

方法

通过 Web of Science、Wiley Online Library、PubMed、中国知网和万方数据库对文献进行检索。标题或摘要检索词为“糖尿病视网膜病变”和“DR”，并与“成纤维细胞生长因子 21”、“FGF21”和“Klotho”相结合。Meta 分析结果以标准化均数差（SMD）及其相应的 95%置信区间（CI）表示。

结果

本 Meta 分析共纳入 15 项研究。DR 患者的 FGF21 水平明显高于非 DR 糖尿病患者（SMD：2.12，95%CI[1.40，2.84]）。DR 患者的 Klotho 水平明显低于非 DR 糖尿病患者（SMD：-0.63，95%CI[-1.22，-0.04]）。

结论

这是第一项评估 FGF21、Klotho 水平与 DR 之间关系的系统评价。DR 患者的 FGF21 水平明显升高。充分阐明 FGF21 的作用将对 DR 的治疗有重大意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/c0cad5576f7d/fendo-15-1390035-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/eaed8ea09d99/fendo-15-1390035-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/7ec96ba9ad94/fendo-15-1390035-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/84d82035088b/fendo-15-1390035-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/ffc45e566ad3/fendo-15-1390035-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/c0cad5576f7d/fendo-15-1390035-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/eaed8ea09d99/fendo-15-1390035-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/7ec96ba9ad94/fendo-15-1390035-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/84d82035088b/fendo-15-1390035-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/ffc45e566ad3/fendo-15-1390035-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/301b/11384578/c0cad5576f7d/fendo-15-1390035-g005.jpg

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