Saini Amit K, Panda Prasan K, Bahurupi Yogesh, Omar Balram, T Akhil, Panwar Pooja, Sharma Maneesh
Department of Nursing, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Cureus. 2022 May 9;14(5):e24840. doi: 10.7759/cureus.24840. eCollection 2022 May.
Background The number of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is vastly underestimated. In this context, seroprevalence surveys are of utmost importance to assess the proportion of the population that has already developed antibodies against the virus and might potentially be protected against subsequent infection. Health care workers (HCWs) face a greater risk of developing SARS-CoV-2. Therefore, the present retrospective study was undertaken to estimate the prevalence of antibodies against SARS-CoV-2 among healthcare workers at a tertiary care institute in Uttarakhand, India. Material and methods Data were gathered from hospital records of 704 healthcare workers admitted to the coronavirus disease 2019 (COVID-19) unit and attended the COVID OPD of the tertiary care institute between July 15 to Aug 14, 2020. Result Out of the 704 recruited participants, 14 (1.99%) were seropositive for immunoglobulin G (IgG) antibodies against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive reverse transcription-polymerase chain reaction (RT-PCR)) was 4.40%. Conclusion The present study shows a low prevalence of SARS-CoV-2 IgG antibodies among health care workers. In addition, posting in COVID-19-positive areas was not associated with increased seropositivity. More studies are warranted to assess IgG/IgM antibodies against SARS-CoV-2 among those HCWs who are exposed to COVID-19 patients.
背景 严重急性呼吸综合征冠状病毒2（SARS-CoV-2）确诊感染病例数被严重低估。在此背景下，血清流行率调查对于评估已产生该病毒抗体、可能对后续感染具有潜在免疫力的人群比例至关重要。医护人员感染SARS-CoV-2的风险更高。因此，本回顾性研究旨在估算印度北阿坎德邦一家三级医疗机构中医护人员抗SARS-CoV-2抗体的流行率。 材料与方法 收集了2020年7月15日至8月14日期间入住该三级医疗机构新冠病毒病（COVID-19）病房并在新冠门诊就诊的704名医护人员的医院记录数据。 结果 在704名招募的参与者中，14人（1.99%）抗SARS-CoV-2免疫球蛋白G（IgG）抗体呈血清阳性。SARS-CoV-2感染的累积流行率（存在抗体或既往或当前逆转录聚合酶链反应（RT-PCR）呈阳性）为4.40%。 结论 本研究显示医护人员中SARS-CoV-2 IgG抗体流行率较低。此外，在COVID-19阳性区域工作与血清阳性率增加无关。有必要开展更多研究以评估接触COVID-19患者的医护人员中抗SARS-CoV-2的IgG/IgM抗体情况。
