Department of Neurosurgery, Chongqing Red Cross Hospital (Jiangbei District People's Hospital), Chongqing, China.
Department of Neurosurgery, Bishan District People's Hospital, Chongqing, China.
Pathol Oncol Res. 2022 May 25;28:1610067. doi: 10.3389/pore.2022.1610067. eCollection 2022.
Glioblastoma (GBM), which occasionally occurs in pediatric patients, is the most common tumor of the central nervous system in adults. Clinically, GBM is classified as low-grade to high-grade (from 1 to 4) and is characterized by late discovery, limited effective treatment methods, and poor efficacy. With the development of immunotherapy technology, effective GBM treatment strategies are of great significance. The main immune cells found in the GBM tumor microenvironment are macrophages and microglia (MG). Both these monocytes play important roles in the occurrence and development of GBM. Macrophages are recruited during tumorigenesis, whereas MG is present in the brain during embryonic development. Interestingly, the accumulation of these monocytes is inversely proportional to the survival of adult GBM patients but not the pediatric GBM patients. This study used single-cell RNA-seq data to reveal the heterogeneity of MG in tumor lesions and to explore the role of different MG subtypes in the occurrence and development of GBM. The results may help find new targets for immunotherapy of GBM.
胶质母细胞瘤（GBM）偶尔发生于儿科患者，是成人中枢神经系统最常见的肿瘤。临床上，GBM 分为低级别到高级别（1 级到 4 级），其特征为发现较晚、有效治疗方法有限、疗效不佳。随着免疫治疗技术的发展，有效的 GBM 治疗策略具有重要意义。GBM 肿瘤微环境中的主要免疫细胞是巨噬细胞和小胶质细胞（MG）。这两种单核细胞在 GBM 的发生和发展中都发挥着重要作用。巨噬细胞在肿瘤发生时被募集，而 MG 则存在于胚胎发育的大脑中。有趣的是，这些单核细胞的积累与成人 GBM 患者的存活率成反比，但与儿科 GBM 患者无关。本研究使用单细胞 RNA-seq 数据揭示了肿瘤病变中 MG 的异质性，并探讨了不同 MG 亚型在 GBM 发生和发展中的作用。研究结果可能有助于为 GBM 的免疫治疗寻找新的靶点。
