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膳食草莓可改善老年人认知能力:一项随机、双盲、安慰剂对照试验。

Dietary strawberry improves cognition in a randomised, double-blind, placebo-controlled trial in older adults.

机构信息

USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

出版信息

Br J Nutr. 2021 Jul 28;126(2):253-263. doi: 10.1017/S0007114521000222. Epub 2021 Jan 20.

Abstract

Functional changes in the brain during ageing can alter learning and memory, gait and balance - in some cases leading to early cognitive decline, disability or injurious falls among older adults. Dietary interventions with strawberry (SB) have been associated with improvements in neuronal, psychomotor and cognitive functions in rodent models of ageing. We hypothesised that dietary supplementation with SB would improve mobility and cognition among older adults. In this study, twenty-two men and fifteen women, between the ages of 60 and 75 years, were recruited into a randomised, double-blind, placebo-controlled trial in which they consumed either freeze-dried SB (24 g/d, equivalent to two cups of fresh SB) or a SB placebo for 90 d. Participants completed a battery of balance, gait and cognitive tests at baseline and again at 45 and 90 d of intervention. Significant supplement group by study visit interactions were observed on tests of learning and memory. Participants in the SB group showed significantly shorter latencies in a virtual spatial navigation task (P = 0·020, ηp2 = 0·106) and increased word recognition in the California Verbal Learning test (P = 0·014, ηp2 = 0·159) across study visits relative to controls. However, no improvement in gait or balance was observed. These findings show that the addition of SB to the diets of healthy, older adults can improve some aspects of cognition, but not gait or balance, although more studies with a larger sample size and longer follow-up are needed to confirm this finding.

摘要

大脑在衰老过程中的功能变化会改变学习和记忆、步态和平衡——在某些情况下,会导致老年人早期认知能力下降、残疾或受伤性跌倒。草莓(SB)的饮食干预与改善衰老啮齿动物模型中的神经元、心理运动和认知功能有关。我们假设 SB 的饮食补充会改善老年人的活动能力和认知能力。在这项研究中,22 名男性和 15 名女性,年龄在 60 至 75 岁之间,被招募到一项随机、双盲、安慰剂对照试验中,他们分别服用冻干 SB(24 克/天,相当于两杯新鲜 SB)或 SB 安慰剂 90 天。参与者在基线和干预 45 天和 90 天完成了一系列平衡、步态和认知测试。在学习和记忆测试中观察到补充剂组与研究访问的显著相互作用。与对照组相比,SB 组的参与者在虚拟空间导航任务中的潜伏期明显缩短(P=0.020,ηp2=0.106),加利福尼亚语言学习测试中的单词识别能力提高(P=0.014,ηp2=0.159)。然而,步态或平衡没有改善。这些发现表明,在健康老年人的饮食中添加 SB 可以改善认知的某些方面,但不能改善步态或平衡,尽管需要更多具有更大样本量和更长随访时间的研究来证实这一发现。

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