Control of Chronic Viral Infections Group, Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Paris, France.
Biomaterials and Microfluidics Core Facility, Institut Pasteur, Paris, France.
J Cell Biol. 2022 Jul 4;221(7). doi: 10.1083/jcb.202206023. Epub 2022 Jun 13.
Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.
Wang 等人在本期（2022 年《细胞生物学杂志》，https://doi.org/10.1083/jcb.202108015）报道称，SARS-CoV-2 蛋白 ORF10 增加了 E3 连接酶 CUL2ZYG11B 的活性，导致多个纤毛蛋白的降解。由此产生的纤毛缺失可能有助于 SARS-CoV-2 在呼吸道内的传播。
