险象环生：SARS-CoV-2 如何引发纤毛的丧失。

A close shave: How SARS-CoV-2 induces the loss of cilia.

机构信息

Control of Chronic Viral Infections Group, Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Paris, France.

Biomaterials and Microfluidics Core Facility, Institut Pasteur, Paris, France.

出版信息

J Cell Biol. 2022 Jul 4;221(7). doi: 10.1083/jcb.202206023. Epub 2022 Jun 13.

DOI:10.1083/jcb.202206023

PMID:35695891

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9198720/

Abstract

Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

摘要

Wang 等人在本期（2022 年《细胞生物学杂志》，https://doi.org/10.1083/jcb.202108015）报道称，SARS-CoV-2 蛋白 ORF10 增加了 E3 连接酶 CUL2ZYG11B 的活性，导致多个纤毛蛋白的降解。由此产生的纤毛缺失可能有助于 SARS-CoV-2 在呼吸道内的传播。