Himeno Ai, Tsujikami Masaya, Koizumi Seiko, Watanabe Toshiro, Igase Michiya
Nitta Gelatin Inc., R&D Center, 2-22 Futamata, Yao-City, Osaka, Japan.
Sonoda Women's University, Hyogo, Japan.
Dermatol Ther (Heidelb). 2022 Jul;12(7):1577-1587. doi: 10.1007/s13555-022-00748-4. Epub 2022 Jun 11.
We examined the effect of 5.0 g/day of collagen peptide (CP) or collagen peptide fermented with Aspergillus sojae (FCP) on skin pigmentation in healthy participants.
In this randomized, double-blind, placebo-controlled study, 44 men and women aged 25-63 years were placed into three groups by stratified random allocation and treated with CP, FCP, or placebo (PL) at 5.0 g/day for 3 months. Their skin condition was measured monthly from baseline to 3 months of intake.
No adverse events were identified in any group. The CP group showed a significant reduction in pigmented patches and redness after 1 and 3 months of intake, respectively. In the FCP group, pigmented macules were significantly reduced after 1 month, and pigmented patches after 2 months. Both the all-ages analysis and the hierarchical analysis below 55 years old yielded similar results.
Intake of 5.0 g/day of FCP for 3 months is safe. CP and FCP intake is useful for suppressing pigmentation. In addition, CP intake may be useful for reducing redness. These results suggest a new beneficial effect on the skin of CP supplementation.
UMIN clinical trials registry system, UMIN000040736.
我们研究了每日5.0克胶原蛋白肽（CP）或经米曲霉发酵的胶原蛋白肽（FCP）对健康受试者皮肤色素沉着的影响。
在这项随机、双盲、安慰剂对照研究中，44名年龄在25至63岁之间的男性和女性通过分层随机分配被分为三组，分别接受每日5.0克的CP、FCP或安慰剂（PL）治疗，为期3个月。从基线到摄入3个月期间，每月测量他们的皮肤状况。
任何组均未发现不良事件。CP组在摄入1个月和3个月后，色素沉着斑和发红情况分别显著减轻。在FCP组中，色素沉着斑在1个月后显著减少，色素沉着块在2个月后显著减少。全年龄段分析和55岁以下分层分析均得出类似结果。
每日摄入5.0克FCP，持续3个月是安全的。摄入CP和FCP有助于抑制色素沉着。此外，摄入CP可能有助于减轻发红。这些结果表明补充CP对皮肤有新的有益作用。
UMIN临床试验注册系统，UMIN000040736。
