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Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans.

作者信息

Ceriello A, Giugliano D, Quatraro A, Marchi E, Barbanti M, Lefèbvre P

机构信息

Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italy.

出版信息

Diabetologia. 1990 Mar;33(3):163-7. doi: 10.1007/BF00404044.

DOI:10.1007/BF00404044
PMID:2184068
Abstract

In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

摘要

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Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
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Fibrinopeptide-A in diabetes mellitus. Relation to levels of blood glucose, fibrinogen disappearance, and hemodynamic changes.糖尿病中的纤维蛋白肽A。与血糖水平、纤维蛋白原清除及血流动力学变化的关系。
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