Adverse reproductive and developmental consequences of quantum dots.

Quantum dots (QDs), with a size of 1-10 nm, are luminescent semiconductor nanocrystals characterized by a shell-core structure. Notably, QDs have potential application in bioimaging owing to their higher fluorescence performance than conventional fluorescent dyes. To date, QDs has been widely used in photovoltaic devices, supercapacitors, electrocatalysis, photocatalysis. In recent years, scientists have focused on whether the use of QDs can interfere with the reproductive and developmental processes of organisms, resulting in serious population and community problems. In this study, we first analyze the possible reproductive and development toxicity of QDs. Next, we summarize the possible mechanisms underlying QDs' interference with reproduction and development, including oxidative stress, altered gametogenesis and fetal development gene expression, autophagy and apoptosis, and release of metal ions. Thereafter, we highlight some potential aspects that can be used to eliminate or reduce QDs toxicity. Based on QDs' unique physical and chemical properties, a comprehensive range of toxicity test data is urgently needed to build structure-activity relationship to quickly evaluate the ecological safety of each kind of QDs.