Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Neurosci Biobehav Rev. 2022 Aug;139:104733. doi: 10.1016/j.neubiorev.2022.104733. Epub 2022 Jun 11.
To understand the pathways through which well-being contributes to health, we performed a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines on the association between well-being and physiological markers in four categories, neurotransmitters, hormones, inflammatory markers, and microbiome. We identified 91 studies. Neurotransmitter studies (k=9) reported only a possible positive association between serotonin and well-being. For the hormone studies (k = 48), a lower momentary cortisol level was related to higher well-being (meta-analytic r = -0.06), and a steeper diurnal slope of cortisol levels. Inflammatory marker studies (k = 36) reported negative or non-significant relations with well-being, with meta-analytic estimates of respectively r = -0.07 and r = -0.05 for C-reactive protein and interleukin-6. Microbiome studies (k = 4) reported inconsistent associations between different bacteria abundance and well-being. The results indicate possible but small roles of serotonin, cortisol, and inflammatory markers in explaining differences in well-being. The inconsistent and limited results for other markers and microbiome require further research. Future directions for a complete picture of the physiological factors underlying well-being are proposed.
为了理解幸福感对健康的影响途径，我们按照系统评价和荟萃分析（PRISMA）指南的要求，对幸福感与神经递质、激素、炎症标志物和微生物组这四个类别的生理标志物之间的关联进行了系统综述。我们共确定了 91 项研究。神经递质研究（k=9）仅报告了血清素与幸福感之间可能存在正相关。对于激素研究（k=48），皮质醇水平的瞬时降低与幸福感的提高有关（元分析 r=-0.06），而皮质醇水平的昼夜斜率则较高。炎症标志物研究（k=36）报告了与幸福感之间的负相关或无显著相关，元分析估计 C 反应蛋白和白细胞介素-6 的 r 分别为-0.07 和-0.05。微生物组研究（k=4）报告了不同细菌丰度与幸福感之间不一致的关联。结果表明，血清素、皮质醇和炎症标志物在解释幸福感差异方面可能发挥了一定作用，但作用较小。其他标志物和微生物组的结果不一致且有限，需要进一步研究。我们提出了一个全面了解幸福感背后的生理因素的未来研究方向。
